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mcsB protein arginine kinase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936939, updated on 16-Oct-2021

Summary

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Gene symbol
mcsB
Gene description
protein arginine kinase
Locus tag
BSU_00850
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU00850
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Genomic context

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Sequence:
NC_000964.3 (102484..103575)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene transcriptional regulator of class III stress genes Neighboring gene activator of protein kinase McsB Neighboring gene class III stress response-related ATPase, AAA+ superfamily Neighboring gene DNA repair protein; 6-O-methylguanine-DNA methyltransferase Neighboring gene diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation. Hajdusits B, et al. Elife, 2021 Jul 30. PMID 34328418, Free PMC Article
  2. Structure of McsB, a protein kinase for regulated arginine phosphorylation. Suskiewicz MJ, et al. Nat Chem Biol, 2019 May. PMID 30962626, Free PMC Article
  3. The tyrosine kinase McsB is a regulated adaptor protein for ClpCP. Kirstein J, et al. EMBO J, 2007 Apr 18. PMID 17380125, Free PMC Article
  4. Activity control of the ClpC adaptor McsB in Bacillus subtilis. Elsholz AK, et al. J Bacteriol, 2011 Aug. PMID 21622759, Free PMC Article
  5. McsA and B mediate the delocalization of competence proteins from the cell poles of Bacillus subtilis. Hahn J, et al. Mol Microbiol, 2009 Apr. PMID 19226326, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.
    Title: McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.
  2. McsB differs in structure and mechanism from protein kinases that act on serine, threonine, and tyrosine residues and instead has a catalytic domain related to that of phosphagen kinases (PhKs), metabolic enzymes that phosphorylate small guanidino compounds.
    Title: Structure of McsB, a protein kinase for regulated arginine phosphorylation.
  3. McsB kinase activity is inhibited by ClpC.
    Title: Activity control of the ClpC adaptor McsB in Bacillus subtilis.
  4. The protein kinase proteins McsA and McsB are needed for delocalization of competence proteins from the cell poles.
    Title: McsA and B mediate the delocalization of competence proteins from the cell poles of Bacillus subtilis.
  5. Under heat-shock conditions, the tyrosine kinase McsB acts as a regulated adaptor protein, which in its phosphorylated form activates the Hsp100/Clp protein ClpC and targets the repressor CtsR for degradation by the general protease ClpCP.
    Title: The tyrosine kinase McsB is a regulated adaptor protein for ClpCP.
  6. McsB, a tyrosine kinase, and its activator McsA, control the activity of the CtsR heat shock repressor in B. subtilis.
    Title: A tyrosine kinase and its activator control the activity of the CtsR heat shock repressor in B. subtilis.
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General gene information

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Homology

General protein information

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Preferred Names
protein arginine kinase
NP_387966.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_387966.1 protein arginine kinase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_387966.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    PRK01059
    Location:4 → 348
    PRK01059; ATP:guanido phosphotransferase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37570.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases