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Klf7 Kruppel-like factor 7 (ubiquitous) [ Mus musculus (house mouse) ]

Gene ID: 93691, updated on 5-Mar-2023

Summary

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Official Symbol
Klf7provided by MGI
Official Full Name
Kruppel-like factor 7 (ubiquitous)provided by MGI
Primary source
MGI:MGI:1935151
See related
Ensembl:ENSMUSG00000025959 AllianceGenome:MGI:1935151
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830124P08Rik
Summary
Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within axon guidance; dendrite morphogenesis; and positive regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including genitourinary system; gut; immune system; nervous system; and sensory organ. Orthologous to human KLF7 (Kruppel like factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 10.9), whole brain E14.5 (RPKM 9.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Klf7 in Genome Data Viewer
Location:
1; 1 C2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (64068607..64161504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (64029448..64122345, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13749 Neighboring gene VISTA enhancer mm997 Neighboring gene microRNA 6899 Neighboring gene predicted gene 13748 Neighboring gene predicted gene, 35880 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene 1_583.1 Neighboring gene predicted gene, 39654

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KLF7 overexpression in bone marrow stromal stem cells graft transplantation promotes sciatic nerve regeneration. Li WY, et al. J Neural Eng, 2019 Aug 12. PMID 31296795
  2. AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury. Li WY, et al. Neural Plast, 2017. PMID 28884027, Free PMC Article
  3. KLF7 Regulates Satellite Cell Quiescence in Response to Extracellular Signaling. Wang X, et al. Stem Cells, 2016 May. PMID 26930448
  4. Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Schuettpelz LG, et al. Blood, 2012 Oct 11. PMID 22936656, Free PMC Article
  5. Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. Blackmore MG, et al. Proc Natl Acad Sci U S A, 2012 May 8. PMID 22529377, Free PMC Article

See all (58) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice.
    Title: The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice.
  2. KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1.
    Title: KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1.
  3. Kruppel-like Transcription Factor 7 Is a Causal Gene in Autism Development.
    Title: Krüppel-like Transcription Factor 7 Is a Causal Gene in Autism Development.
  4. Methylation of miR-19b-3p promoter exacerbates inflammatory responses in sepsis-induced ALI via targeting KLF7.
    Title: Methylation of miR-19b-3p promoter exacerbates inflammatory responses in sepsis-induced ALI via targeting KLF7.
  5. MicroRNA-136-3p inhibits glioma tumorigenesis in vitro and in vivo by targeting KLF7.
    Title: MicroRNA-136-3p inhibits glioma tumorigenesis in vitro and in vivo by targeting KLF7.
  6. KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity.
    Title: KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity.
  7. KLF7 overexpression in bone marrow stromal stem cells graft transplantation promotes sciatic nerve regeneration.
    Title: KLF7 overexpression in bone marrow stromal stem cells graft transplantation promotes sciatic nerve regeneration.
  8. Mechanistically, KLF7 transcriptionally activated argininosuccinate lyase (ASL), which was observed highly expressed in glioma tissues. KLF7 accelerates the xenografted tumor growth of glioma cells. KLF7 potentiates polyamine biosynthesis and glioma cell growth via transcriptionally activates ASL.
    Title: KLF7 promotes polyamine biosynthesis and glioma development through transcriptionally activating ASL.
  9. Our findings suggest that KLF7 promotes DPSN axonal plasticity and the formation of synapses with motor neurons at the caudal spinal cord, leading to improved functional recovery
    Title: AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury.
  10. was upregulated in quiescent satellite cell and nonproliferating myoblasts.
    Title: KLF7 Regulates Satellite Cell Quiescence in Response to Extracellular Signaling.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epidermal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Krueppel-like factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033563.2 → NP_291041.2  Krueppel-like factor 7

    See identical proteins and their annotated locations for NP_291041.2

    Status: PROVISIONAL

    Source sequence(s)
    BC019604
    Consensus CDS
    CCDS15003.1
    UniProtKB/Swiss-Prot
    Q99JB0, Q99P62
    UniProtKB/TrEMBL
    A0A6P5PTY9, A0A8C6GUC5
    Related
    ENSMUSP00000109720.3, ENSMUST00000114086.8
    Conserved Domains (5) summary
    COG5048
    Location:211 → 283
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:264 → 289
    zf-H2C2_2; Zinc-finger double domain
    cd21585
    Location:2 → 219
    KLF7_N; N-terminal domain of Kruppel-like factor 7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    64068607..64161504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243769.1 → XP_030099629.1  Krueppel-like factor 7 isoform X2

    UniProtKB/Swiss-Prot
    Q99P62
    UniProtKB/TrEMBL
    A0A6P5PTY9, A0A8C6GUC5
    Conserved Domains (5) summary
    COG5048
    Location:211 → 283
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:264 → 289
    zf-H2C2_2; Zinc-finger double domain
    cd21585
    Location:2 → 219
    KLF7_N; N-terminal domain of Kruppel-like factor 7

  2. XM_030243770.1 → XP_030099630.1  Krueppel-like factor 7 isoform X2

    UniProtKB/Swiss-Prot
    Q99P62
    UniProtKB/TrEMBL
    A0A6P5PTY9, A0A8C6GUC5
    Conserved Domains (5) summary
    COG5048
    Location:211 → 283
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:264 → 289
    zf-H2C2_2; Zinc-finger double domain
    cd21585
    Location:2 → 219
    KLF7_N; N-terminal domain of Kruppel-like factor 7

  3. XM_006496352.5 → XP_006496415.1  Krueppel-like factor 7 isoform X1

    See identical proteins and their annotated locations for XP_006496415.1

    Conserved Domains (5) summary
    COG5048
    Location:223 → 281
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279 → 301
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:265 → 290
    zf-H2C2_2; Zinc-finger double domain
    cd21585
    Location:2 → 219
    KLF7_N; N-terminal domain of Kruppel-like factor 7

  4. XM_006496353.4 → XP_006496416.1  Krueppel-like factor 7 isoform X1

    See identical proteins and their annotated locations for XP_006496416.1

    Conserved Domains (5) summary
    COG5048
    Location:223 → 281
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279 → 301
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:265 → 290
    zf-H2C2_2; Zinc-finger double domain
    cd21585
    Location:2 → 219
    KLF7_N; N-terminal domain of Kruppel-like factor 7

  5. XM_006496354.4 → XP_006496417.1  Krueppel-like factor 7 isoform X2

    See identical proteins and their annotated locations for XP_006496417.1

    UniProtKB/Swiss-Prot
    Q99JB0, Q99P62
    UniProtKB/TrEMBL
    A0A6P5PTY9, A0A8C6GUC5
    Conserved Domains (5) summary
    COG5048
    Location:211 → 283
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:264 → 289
    zf-H2C2_2; Zinc-finger double domain
    cd21585
    Location:2 → 219
    KLF7_N; N-terminal domain of Kruppel-like factor 7

  6. XM_006496351.4 → XP_006496414.1  Krueppel-like factor 7 isoform X1

    See identical proteins and their annotated locations for XP_006496414.1

    Conserved Domains (5) summary
    COG5048
    Location:223 → 281
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279 → 301
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:265 → 290
    zf-H2C2_2; Zinc-finger double domain
    cd21585
    Location:2 → 219
    KLF7_N; N-terminal domain of Kruppel-like factor 7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JB0.1 GenPept UniProtKB/Swiss-Prot:Q99JB0

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