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NRXN3 neurexin 3 [ Homo sapiens (human) ]

Gene ID: 9369, updated on 6-Oct-2018

Summary

Official Symbol
NRXN3provided by HGNC
Official Full Name
neurexin 3provided by HGNC
Primary source
HGNC:HGNC:8010
See related
Ensembl:ENSG00000021645 MIM:600567; Vega:OTTHUMG00000171502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf60
Summary
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
Expression
Biased expression in brain (RPKM 7.1), adrenal (RPKM 1.0) and 11 other tissues See more
Orthologs

Genomic context

See NRXN3 in Genome Data Viewer
Location:
14q24.3-q31.1
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (77979904..79868290)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (78636716..80334633)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370581 Neighboring gene aarF domain containing kinase 1 Neighboring gene transfer RNA suppressor (CTA) 3-1 Neighboring gene RNA, 5S ribosomal pseudogene 388 Neighboring gene frataxin pseudogene 1 Neighboring gene ribosomal protein S26 pseudogene 48 Neighboring gene uncharacterized LOC105370589 Neighboring gene uncharacterized LOC107984629 Neighboring gene uncharacterized LOC105370588 Neighboring gene uncharacterized LOC105370587 Neighboring gene uncharacterized LOC105370586 Neighboring gene uncharacterized LOC112268125 Neighboring gene uncharacterized LOC105370583 Neighboring gene VISTA enhancer hs1369 Neighboring gene uncharacterized LOC105370582 Neighboring gene uncharacterized LOC107984630 Neighboring gene uncharacterized LOC112267892

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study on obesity and obesity-related traits.
NHGRI GWA Catalog
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
NHGRI GWA Catalog
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Common genetic variation and performance on standardized cognitive tests.
NHGRI GWA Catalog
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
NHGRI GWA Catalog
Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
NHGRI GWA Catalog
Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NRXN3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Interactions of neurexins and neuroligins at synapses, organism-specific biosystem (from REACTOME)
    Interactions of neurexins and neuroligins at synapses, organism-specific biosystemNeurexins (NRXNs) and neuroligins (NLGNs) are best characterized synaptic cell-adhesion molecules. They are part of excitatory glutamatergic and inhibitory GABAergic synapses in mammalian brain, medi...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38928, FLJ44845, KIAA0743, MGC176711

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
neuroligin family protein binding TAS
Traceable Author Statement
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
adult behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
axon guidance TAS
Traceable Author Statement
more info
PubMed 
learning IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron cell-cell adhesion TAS
Traceable Author Statement
more info
PubMed 
social behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
vocalization behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neurexin 3
Names
neurexin III
neurexin-3-alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052991.1 RefSeqGene

    Range
    5001..1702918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105250.2NP_001098720.1  neurexin 3 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001098720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform.
    Source sequence(s)
    AF123462, BC150194, DA243312
    Consensus CDS
    CCDS45145.1
    UniProtKB/Swiss-Prot
    Q9HDB5
    Related
    ENSP00000394426.2, OTTHUMP00000246250, ENST00000428277.6, OTTHUMT00000413792
    Conserved Domains (2) summary
    cd00110
    Location:86265
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:385420
    Syndecan; Syndecan domain
  2. NM_001272020.1NP_001258949.1  neurexin 3 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001258949.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform.
    Source sequence(s)
    AF123462, AK056530, BC150194
    Consensus CDS
    CCDS61515.1
    UniProtKB/Swiss-Prot
    Q9HDB5
    Related
    ENSP00000451672.1, OTTHUMP00000246248, ENST00000557594.5, OTTHUMT00000413790
    Conserved Domains (2) summary
    cd00110
    Location:86235
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:563598
    Syndecan; Syndecan domain
  3. NM_001330195.1NP_001317124.1  neurexin 3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7)
    Source sequence(s)
    AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462
    Consensus CDS
    CCDS81831.1
    UniProtKB/TrEMBL
    A0A0U1RRJ0
    Related
    ENSP00000489551.1, ENST00000635466.1
    Conserved Domains (6) summary
    smart00282
    Location:282413
    LamG; Laminin G domain
    cd00054
    Location:647680
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:14971532
    Syndecan; Syndecan domain
    pfam02210
    Location:8991027
    Laminin_G_2; Laminin G domain
  4. NM_001366425.1NP_001353354.1  neurexin 3 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462
  5. NM_001366426.1NP_001353355.1  neurexin 3 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462
  6. NM_004796.5NP_004787.2  neurexin 3 isoform 1

    See identical proteins and their annotated locations for NP_004787.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC026888, AF123462, BC150194, BC152457, DA213090
    Consensus CDS
    CCDS9870.1
    UniProtKB/Swiss-Prot
    Q9HDB5, Q9Y4C0
    Related
    ENSP00000451648.1, OTTHUMP00000246246, ENST00000554719.5, OTTHUMT00000413787
    Conserved Domains (5) summary
    smart00282
    Location:97246
    LamG; Laminin G domain
    cd00054
    Location:274307
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:718867
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:9871022
    Syndecan; Syndecan domain
    pfam02210
    Location:526654
    Laminin_G_2; Laminin G domain
  7. NM_138970.4NP_620426.2  neurexin 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_620426.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform.
    Source sequence(s)
    AF123462, AK056530, BC059368, BC150194
    Consensus CDS
    CCDS9871.1
    UniProtKB/Swiss-Prot
    Q9HDB5
    Related
    ENSP00000281127.7, OTTHUMP00000246249, ENST00000281127.11, OTTHUMT00000413791
    Conserved Domains (2) summary
    cd00110
    Location:86235
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:358393
    Syndecan; Syndecan domain

RNA

  1. NR_073546.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains multiple differences in its 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF123462, AJ493127, AK056530, BC150194
  2. NR_073547.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains multiple differences in its 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF123462, AJ316284, BC150194, DA083962
  3. NR_158973.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462
  4. NR_158974.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462
  5. NR_158975.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    77979904..79868290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021791.1XP_016877280.1  neurexin 3 isoform X1

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:16131648
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  2. XM_017021790.1XP_016877279.1  neurexin 3 isoform X1

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:16131648
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  3. XM_011537364.2XP_011535666.1  neurexin 3 isoform X1

    See identical proteins and their annotated locations for XP_011535666.1

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:16131648
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  4. XM_011537363.1XP_011535665.1  neurexin 3 isoform X1

    See identical proteins and their annotated locations for XP_011535665.1

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:16131648
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  5. XM_011537368.1XP_011535670.1  neurexin 3 isoform X14

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:15121547
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  6. XM_011537371.1XP_011535673.1  neurexin 3 isoform X20

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:14051440
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  7. XM_011537369.1XP_011535671.1  neurexin 3 isoform X15

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:15091544
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  8. XM_011537372.1XP_011535674.1  neurexin 3 isoform X21

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:14021437
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  9. XM_011537367.1XP_011535669.1  neurexin 3 isoform X10

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:15831618
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  10. XM_017021807.1XP_016877296.1  neurexin 3 isoform X25

  11. XM_017021800.1XP_016877289.1  neurexin 3 isoform X17

  12. XM_011537373.1XP_011535675.1  neurexin 3 isoform X26

    See identical proteins and their annotated locations for XP_011535675.1

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:13721407
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  13. XM_017021793.1XP_016877282.1  neurexin 3 isoform X5

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:16041639
    Syndecan; Syndecan domain
    pfam02210
    Location:9021030
    Laminin_G_2; Laminin G domain
  14. XM_017021804.1XP_016877293.1  neurexin 3 isoform X23

    Related
    ENSP00000450683.1, ENST00000554738.5
  15. XM_024449750.1XP_024305518.1  neurexin 3 isoform X12

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:15741609
    Syndecan; Syndecan domain
    pfam02210
    Location:9021030
    Laminin_G_2; Laminin G domain
  16. XM_017021801.1XP_016877290.1  neurexin 3 isoform X18

  17. XM_011537366.1XP_011535668.1  neurexin 3 isoform X4

    See identical proteins and their annotated locations for XP_011535668.1

    Conserved Domains (6) summary
    smart00282
    Location:286417
    LamG; Laminin G domain
    cd00054
    Location:651684
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:16051640
    Syndecan; Syndecan domain
    pfam02210
    Location:9031031
    Laminin_G_2; Laminin G domain
  18. XM_011537370.1XP_011535672.1  neurexin 3 isoform X16

    See identical proteins and their annotated locations for XP_011535672.1

    Conserved Domains (6) summary
    smart00282
    Location:286417
    LamG; Laminin G domain
    cd00054
    Location:651684
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:15011536
    Syndecan; Syndecan domain
    pfam02210
    Location:9031031
    Laminin_G_2; Laminin G domain
  19. XM_017021803.2XP_016877292.1  neurexin 3 isoform X22

  20. XM_006720322.2XP_006720385.1  neurexin 3 isoform X3

    Conserved Domains (6) summary
    smart00282
    Location:282421
    LamG; Laminin G domain
    cd00054
    Location:655688
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:16091644
    Syndecan; Syndecan domain
    pfam02210
    Location:9071035
    Laminin_G_2; Laminin G domain
  21. XM_024449752.1XP_024305520.1  neurexin 3 isoform X27

    Conserved Domains (6) summary
    smart00282
    Location:282421
    LamG; Laminin G domain
    cd00054
    Location:655688
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:13981433
    Syndecan; Syndecan domain
    pfam02210
    Location:9071035
    Laminin_G_2; Laminin G domain
  22. XM_017021794.1XP_016877283.1  neurexin 3 isoform X6

  23. XM_017021805.1XP_016877294.1  neurexin 3 isoform X24

  24. XM_017021802.2XP_016877291.1  neurexin 3 isoform X19

  25. XM_017021798.1XP_016877287.1  neurexin 3 isoform X9

  26. XM_024449751.1XP_024305519.1  neurexin 3 isoform X13

    Conserved Domains (6) summary
    smart00282
    Location:282413
    LamG; Laminin G domain
    cd00054
    Location:647680
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:15621597
    Syndecan; Syndecan domain
    pfam02210
    Location:8901018
    Laminin_G_2; Laminin G domain
  27. XM_024449753.1XP_024305521.1  neurexin 3 isoform X28

    Conserved Domains (6) summary
    smart00282
    Location:282413
    LamG; Laminin G domain
    cd00054
    Location:647680
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:13511386
    Syndecan; Syndecan domain
    pfam02210
    Location:8901018
    Laminin_G_2; Laminin G domain
  28. XM_017021797.1XP_016877286.1  neurexin 3 isoform X8

  29. XM_005268218.3XP_005268275.1  neurexin 3 isoform X2

    See identical proteins and their annotated locations for XP_005268275.1

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:16101645
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain
  30. XM_017021799.2XP_016877288.1  neurexin 3 isoform X11

  31. XM_017021796.2XP_016877285.1  neurexin 3 isoform X7

    Related
    ENSP00000488920.1, OTTHUMP00000281268, ENST00000634499.1
  32. XM_017021792.1XP_016877281.1  neurexin 3 isoform X3

    Conserved Domains (6) summary
    smart00282
    Location:282421
    LamG; Laminin G domain
    cd00054
    Location:655688
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:16091644
    Syndecan; Syndecan domain
    pfam02210
    Location:9071035
    Laminin_G_2; Laminin G domain
  33. XM_011537365.2XP_011535667.1  neurexin 3 isoform X1

    See identical proteins and their annotated locations for XP_011535667.1

    Conserved Domains (6) summary
    smart00282
    Location:286425
    LamG; Laminin G domain
    cd00054
    Location:659692
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:35181
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:202232
    EGF; EGF-like domain
    pfam01034
    Location:16131648
    Syndecan; Syndecan domain
    pfam02210
    Location:9111039
    Laminin_G_2; Laminin G domain

RNA

  1. XR_001750599.1 RNA Sequence

  2. XR_001750600.1 RNA Sequence

  3. XR_001750606.1 RNA Sequence

  4. XR_001750607.1 RNA Sequence

  5. XR_002957572.1 RNA Sequence

  6. XR_001750602.1 RNA Sequence

  7. XR_001750601.1 RNA Sequence

  8. XR_001750608.1 RNA Sequence

  9. XR_001750604.1 RNA Sequence

  10. XR_001750605.1 RNA Sequence

  11. XR_001750603.1 RNA Sequence

  12. XR_943561.1 RNA Sequence

  13. XR_943563.2 RNA Sequence

  14. XR_001750610.1 RNA Sequence

  15. XR_001750609.1 RNA Sequence

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