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ctsR transcriptional regulator of class III stress genes [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936883, updated on 12-Feb-2021
Gene symbol
ctsR
Gene description
transcriptional regulator of class III stress genes
Locus tag
BSU_00830
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU00830
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Sequence:
NC_000964.3 (101449..101913)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene ribosomal RNA-23S Neighboring gene ribosomal RNA-5S Neighboring gene activator of protein kinase McsB Neighboring gene protein arginine kinase Neighboring gene class III stress response-related ATPase, AAA+ superfamily

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of Novel Spx Regulatory Pathways in Bacillus subtilis Uncovers a Close Relationship between the CtsR and Spx Regulons. Rojas-Tapias DF, et al. J Bacteriol, 2019 Jul 1. PMID 30962353, Free PMC Article
  2. CtsR inactivation during thiol-specific stress in low GC, Gram+ bacteria. Elsholz AK, et al. Mol Microbiol, 2011 Feb. PMID 21208299
  3. A tyrosine kinase and its activator control the activity of the CtsR heat shock repressor in B. subtilis. Kirstein J, et al. EMBO J, 2005 Oct 5. PMID 16163393, Free PMC Article
  4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic studies reveal that dysregulation of the CtsR regulon or inactivation of the YwlE phosphoarginine phosphatase decreases Spx activity through mechanisms involving both protein degradation and posttranslational modification.
    Title: Identification of Novel Spx Regulatory Pathways in Bacillus subtilis Uncovers a Close Relationship between the CtsR and Spx Regulons.
  2. The Zn finger protein ClpE is able to sense and respond to oxidative stress, also resulting in CtsR inactivation.
    Title: CtsR inactivation during thiol-specific stress in low GC, Gram+ bacteria.
  3. The heat shock repressor CtsR, whose activity is regulated by its modulators McsA and McsB, controls the expression of the cellular protein quality control genes clpC, clpE and clpP.
    Title: A tyrosine kinase and its activator control the activity of the CtsR heat shock repressor in B. subtilis.
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Homology

Preferred Names
transcriptional regulator of class III stress genes
NP_387964.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_387964.1 transcriptional regulator of class III stress genes [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_387964.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    COG4463
    Location:2 → 154
    CtsR; Transcriptional regulator CtsR [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37568.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases