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Csnk1a1 casein kinase 1, alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 93687, updated on 6-Nov-2022

Summary

Official Symbol
Csnk1a1provided by MGI
Official Full Name
casein kinase 1, alpha 1provided by MGI
Primary source
MGI:MGI:1934950
See related
Ensembl:ENSMUSG00000024576 AllianceGenome:MGI:1934950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK1a; Csnk1a; 2610208K14Rik; 4632404G05Rik; 5430427P18Rik
Summary
Enables protein kinase activity. Involved in protein phosphorylation. Acts upstream of or within cell morphogenesis. Located in ciliary basal body. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; endocrine gland; metanephros; retina nuclear layer; and thymus primordium. Orthologous to several human genes including CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 23.9), bladder adult (RPKM 23.5) and 28 other tissues See more
Orthologs
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Genomic context

See Csnk1a1 in Genome Data Viewer
Location:
18; 18 E1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61687307..61723391)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61554236..61590320)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46637 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 37 Neighboring gene VISTA enhancer mm36 Neighboring gene predicted gene, 41747

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29354, MGC30571

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intermediate filament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of GTP binding ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of beta-catenin destruction complex IC
Inferred by Curator
more info
PubMed 
part_of beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium TAS
Traceable Author Statement
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with keratin filament ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
part_of mRNA cleavage and polyadenylation specificity factor complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
casein kinase I isoform alpha; casein kinase I
Names
CK1
CKI-alpha
casein kinase I-alpha
NP_001344427.1
NP_001344428.1
NP_001344429.1
NP_666199.1
XP_006526446.1
XP_006526449.1
XP_011245350.1
XP_030106505.1
XP_030106506.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357498.1NP_001344427.1  casein kinase I isoform alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153155, AI853067
    Consensus CDS
    CCDS89252.1
    UniProtKB/TrEMBL
    A0A6P5NXJ4, A0A8C6GCN3, E9Q3W1
    Related
    ENSMUSP00000127265.2, ENSMUST00000170862.8
    Conserved Domains (1) summary
    cd14128
    Location:16309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
  2. NM_001357499.1NP_001344428.1  casein kinase I isoform alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153155, AI853067
    Consensus CDS
    CCDS89251.1
    UniProtKB/TrEMBL
    A0A6P5NSM4, E9Q2U6
    Related
    ENSMUSP00000127463.2, ENSMUST00000167187.8
    Conserved Domains (1) summary
    cd14128
    Location:16309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
  3. NM_001357500.1NP_001344429.1  casein kinase I isoform alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153155, AI853067
    Consensus CDS
    CCDS89254.1
    UniProtKB/Swiss-Prot
    Q99LY3
    UniProtKB/TrEMBL
    A0A6P5NVE3, A0A8C6MQB5
    Related
    ENSMUSP00000132083.2, ENSMUST00000165721.8
    Conserved Domains (1) summary
    cd14128
    Location:16281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
  4. NM_146087.3NP_666199.1  casein kinase I isoform alpha isoform 1

    See identical proteins and their annotated locations for NP_666199.1

    Status: VALIDATED

    Source sequence(s)
    AC153155, AI853067, AK076070, AK146873, BY065893
    Consensus CDS
    CCDS37838.1
    UniProtKB/TrEMBL
    A0A6P5NY09, Q6PJ87
    Related
    ENSMUSP00000128871.2, ENSMUST00000165123.8
    Conserved Domains (1) summary
    cd14128
    Location:16281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61687307..61723391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247048.3XP_011245350.1  casein kinase I isoform X1

    Conserved Domains (1) summary
    cd14128
    Location:16309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
  2. XM_006526383.4XP_006526446.1  casein kinase I isoform X2

    UniProtKB/TrEMBL
    A0A6P5NVD8
    Conserved Domains (1) summary
    cd14128
    Location:16309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
  3. XM_006526386.4XP_006526449.1  casein kinase I isoform X3

    UniProtKB/TrEMBL
    A0A6P5NY04, A0A8C6MPT7
    Conserved Domains (1) summary
    cd14128
    Location:16309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
  4. XM_030250645.1XP_030106505.1  casein kinase I isoform X4

    UniProtKB/TrEMBL
    A0A6P5P195
    Related
    ENSMUSP00000127144.2, ENSMUST00000163205.8
    Conserved Domains (1) summary
    cd14128
    Location:16281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
  5. XM_030250646.1XP_030106506.1  casein kinase I isoform X5

    UniProtKB/TrEMBL
    A0A6P5NXJ9, H7BXB1
    Related
    ENSMUSP00000110901.3, ENSMUST00000115246.9
    Conserved Domains (1) summary
    cd14128
    Location:16281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

RNA

  1. XR_386022.4 RNA Sequence

  2. XR_386023.4 RNA Sequence