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Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 [ Mus musculus (house mouse) ]

Gene ID: 93685, updated on 12-Apr-2023

Summary

Official Symbol
Entpd7provided by MGI
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 7provided by MGI
Primary source
MGI:MGI:2135885
See related
Ensembl:ENSMUSG00000025192 AllianceGenome:MGI:2135885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LALP1; Lysal2; 1810012B13Rik; 1810020C02Rik; 2810003F23Rik
Summary
Enables nucleoside-triphosphatase activity. Involved in T-helper 17 cell differentiation and regulation of immune response. Predicted to be located in cytoplasmic vesicle membrane and nucleus. Predicted to be active in Golgi apparatus and membrane. Orthologous to human ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 10.3), duodenum adult (RPKM 9.0) and 27 other tissues See more
Orthologs
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Genomic context

See Entpd7 in Genome Data Viewer
Location:
19; 19 C3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43678128..43722292)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43689689..43733853)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:43749453-43749636 Neighboring gene cDNA sequence BC037704 Neighboring gene cytochrome c oxidase assembly protein 15 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:43827372-43827481 Neighboring gene cutC copper transporter

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ribonucleoside triphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
ectonucleoside triphosphate diphosphohydrolase 7
Names
NTPDase 7
lysosomal apyrase-like 2
lysosomal apyrase-like protein 1
NP_444333.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053103.5NP_444333.3  ectonucleoside triphosphate diphosphohydrolase 7

    See identical proteins and their annotated locations for NP_444333.3

    Status: VALIDATED

    Source sequence(s)
    AC141888, AK147401, BY773413
    Consensus CDS
    CCDS29835.1
    UniProtKB/Swiss-Prot
    Q3TCT4, Q9ET10
    Related
    ENSMUSP00000079864.6, ENSMUST00000081079.6
    Conserved Domains (1) summary
    cl17037
    Location:77527
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    43678128..43722292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)