U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

degU two-component response regulator [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936751, updated on 6-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
degU
Gene description
two-component response regulator
Locus tag
BSU_35490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU35490
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000964.3 (3644607..3645296, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene ATP-dependent helicase competence protein Neighboring gene fatty acid kinase fatty acid binding subunit A Neighboring gene two-component sensor histidine kinase [DegU] Neighboring gene putative translation regulator Neighboring gene teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Rampant loss of social traits during domestication of a Bacillus subtilis natural isolate. Barreto HC, et al. Sci Rep, 2020 Nov 3. PMID 33144634, Free PMC Article
  2. Involvement of nitrogen regulation in Bacillus subtilis degU expression. Yasumura A, et al. J Bacteriol, 2008 Aug. PMID 18502860, Free PMC Article
  3. Bacillus subtilis response regulator DegU is a direct activator of pgsB transcription involved in gamma-poly-glutamic acid synthesis. Ohsawa T, et al. Biosci Biotechnol Biochem, 2009 Sep. PMID 19734658
  4. Characterization of DegU-dependent expression of bpr in Bacillus subtilis. Tsukahara K, et al. FEMS Microbiol Lett, 2008 Mar. PMID 18194340
  5. The Bacillus subtilis response regulator gene degU is positively regulated by CcpA and by catabolite-repressed synthesis of ClpC. Ishii H, et al. J Bacteriol, 2013 Jan. PMID 23123903, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rampant loss of social traits during domestication of a Bacillus subtilis natural isolate.
    Title: Rampant loss of social traits during domestication of a Bacillus subtilis natural isolate.
  2. Bacillus subtilis hag mutants lack functional and structural flagellar components and display reduced transformation frequency. The impaired competence is due to an increase in the phosphorylated form of the response regulator DegU, which is involved in regulation of both flagellar motility and competence.
    Title: Impaired competence in flagellar mutants of Bacillus subtilis is connected to the regulatory network governed by DegU.
  3. Hyperphosphorylation of DegU cancels CcpA-dependent catabolite repression of rocG in Bacillus subtilis.
    Title: Hyperphosphorylation of DegU cancels CcpA-dependent catabolite repression of rocG in Bacillus subtilis.
  4. The role of SwrA, DegU and P(D3) in fla/che expression in B. subtilis.
    Title: The role of SwrA, DegU and P(D3) in fla/che expression in B. subtilis.
  5. An electrophoretic mobility shift assay (EMSA) showed that SinR bound to the degU promoter and that SlrR formed a complex with SinR on the degU promoter.
    Title: Regulation of the response regulator gene degU through the binding of SinR/SlrR and exclusion of SinR/SlrR by DegU in Bacillus subtilis.
  6. High levels of phosphorylated DegU activate an Esat-6-like secretion system in Bacillus subtilis.
    Title: High levels of DegU-P activate an Esat-6-like secretion system in Bacillus subtilis.
  7. Thus, degU is induced through activation of autoregulation by a decrease in ClpCP-dependent proteolysis of DegU-P.
    Title: The Bacillus subtilis response regulator gene degU is positively regulated by CcpA and by catabolite-repressed synthesis of ClpC.
  8. Western blot analysis of DegU in disruption mutants of genes encoding various ATP-dependent proteases strongly suggested that ClpCP degrades DegU.
    Title: Autoregulation of the Bacillus subtilis response regulator gene degU is coupled with the proteolysis of DegU-P by ClpCP.
  9. six-base deletion within the sequence (the -44 to -39 region) abolished DegU-binding to the pgsB promoter and pgsB transcription, confirming the importance of the sequence for DegU-dependent regulation of pgsB
    Title: Bacillus subtilis response regulator DegU is a direct activator of pgsB transcription involved in gamma-poly-glutamic acid synthesis.
  10. These results suggest that degU expression is controlled by the three promoters under different growth conditions.
    Title: Involvement of nitrogen regulation in Bacillus subtilis degU expression.
Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
two-component response regulator
NP_391429.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    3644607..3645296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_391429.1 two-component response regulator [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_391429.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1IA59
    Conserved Domains (1) summary
    COG2197
    Location:5 → 228
    CitB; DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13800.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials