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Tac4 tachykinin 4 [ Mus musculus (house mouse) ]

Gene ID: 93670, updated on 9-May-2024

Summary

Official Symbol
Tac4provided by MGI
Official Full Name
tachykinin 4provided by MGI
Primary source
MGI:MGI:1931130
See related
Ensembl:ENSMUSG00000020872 AllianceGenome:MGI:1931130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PPT-C
Summary
Enables receptor ligand activity; substance K receptor binding activity; and substance P receptor binding activity. Involved in positive regulation of cytosolic calcium ion concentration. Acts upstream of or within positive regulation of saliva secretion and tachykinin receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; mammary gland; skin; spleen; and stomach. Orthologous to human TAC4 (tachykinin precursor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Tac4 in Genome Data Viewer
Location:
11 D; 11 59.01 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95152355..95160091)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95261529..95269265)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:95045922-95046123 Neighboring gene predicted gene, 53255 Neighboring gene STARR-seq mESC enhancer starr_30493 Neighboring gene predicted gene 11515 Neighboring gene K(lysine) acetyltransferase 7 Neighboring gene STARR-positive B cell enhancer ABC_E9370 Neighboring gene STARR-positive B cell enhancer ABC_E9840 Neighboring gene STARR-positive B cell enhancer ABC_E376 Neighboring gene STARR-positive B cell enhancer ABC_E1841 Neighboring gene predicted gene 11520

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables substance K receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables substance K receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables substance P receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables substance P receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables substance P receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in detection of temperature stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of saliva secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in tachykinin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within tachykinin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tachykinin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tachykinin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tachykinin-4
Names
hemokinin I (HK-1)
preprotachykinin-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053093.2NP_444323.1  tachykinin-4 preproprotein

    See identical proteins and their annotated locations for NP_444323.1

    Status: VALIDATED

    Source sequence(s)
    AF235035, AW489379
    Consensus CDS
    CCDS25274.1
    UniProtKB/Swiss-Prot
    Q99N14
    Related
    ENSMUSP00000021242.5, ENSMUST00000021242.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    95152355..95160091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)