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RAB9A RAB9A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 9367, updated on 21-Dec-2019

Summary

Official Symbol
RAB9Aprovided by HGNC
Official Full Name
RAB9A, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9792
See related
Ensembl:ENSG00000123595 MIM:300284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAB9
Expression
Ubiquitous expression in adrenal (RPKM 21.5), bone marrow (RPKM 11.2) and 25 other tissues See more
Orthologs

Genomic context

See RAB9A in Genome Data Viewer
Location:
Xp22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (13689121..13710504)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (13707240..13727944)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985657 Neighboring gene uncharacterized LOC107985656 Neighboring gene transcription elongation factor A N-terminal and central domain containing Neighboring gene trafficking protein particle complex 2 Neighboring gene OFD1 centriole and centriolar satellite protein Neighboring gene glycoprotein M6B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RAB9A, member RAS oncogene family (RAB9A) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef disrupts Rab9-GCC2 interaction (in HEK-293 cells) resulting in delocalization of CI-MPR resulting in elevated secretion of hexosaminidase in HEK-293 cells PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with Rab9 and TGN38 in endosomes and trans-Golgi compartments PubMed
gag HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells PubMed
gag Depletion of Rab9 by siRNA sequesters HIV-1 Gag within cells and causes a reduction in particle release PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation by host of symbiont molecular function IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
melanosome ISS
Inferred from Sequence or Structural Similarity
more info
 
phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network membrane TAS
Traceable Author Statement
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein Rab-9A
Names
RAB9, member RAS oncogene family

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195328.1NP_001182257.1  ras-related protein Rab-9A

    See identical proteins and their annotated locations for NP_001182257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK290505, BC017265, CF528703, DA141710
    Consensus CDS
    CCDS14156.1
    UniProtKB/Swiss-Prot
    P51151
    UniProtKB/TrEMBL
    A0A024RBV5
    Related
    ENSP00000480777.1, ENST00000618931.2
    Conserved Domains (1) summary
    cd04116
    Location:3172
    Rab9; Rab GTPase family 9 (Rab9)
  2. NM_004251.5NP_004242.1  ras-related protein Rab-9A

    See identical proteins and their annotated locations for NP_004242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC003037, BC017265, CF528703, DA141710
    Consensus CDS
    CCDS14156.1
    UniProtKB/Swiss-Prot
    P51151
    UniProtKB/TrEMBL
    A0A024RBV5
    Related
    ENSP00000420127.1, ENST00000464506.2
    Conserved Domains (1) summary
    cd04116
    Location:3172
    Rab9; Rab GTPase family 9 (Rab9)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    13689121..13710504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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