Format

Send to:

Choose Destination

CAPZA3 capping actin protein of muscle Z-line subunit alpha 3 [ Homo sapiens (human) ]

Gene ID: 93661, updated on 1-Jun-2020

Summary

Official Symbol
CAPZA3provided by HGNC
Official Full Name
capping actin protein of muscle Z-line subunit alpha 3provided by HGNC
Primary source
HGNC:HGNC:24205
See related
Ensembl:ENSG00000177938 MIM:608722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gsg3; CAPPA3; HEL-S-86
Summary
This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See CAPZA3 in Genome Data Viewer
Location:
12p12.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (18738119..18739188)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (18891045..18892122)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Neighboring gene zinc finger with KRAB and SCAN domains 7 pseudogene 1 Neighboring gene phospholipase C zeta 1 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 9 Neighboring gene uncharacterized LOC102724227 Neighboring gene uncharacterized LOC107984527

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of the five-factor model of personality in young Korean women.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
F-actin capping protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cortical cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
F-actin-capping protein subunit alpha-3
Names
CP-alpha-3
CapZ alpha-3
F-actin capping protein alpha-3 subunit
capping actin protein of muscle Z-line alpha subunit 3
capping protein (actin filament) muscle Z-line, alpha 3
epididymis secretory protein Li 86
germ cell-specific protein 3
testis tissue sperm-binding protein Li 73n

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033328.3NP_201585.1  F-actin-capping protein subunit alpha-3

    See identical proteins and their annotated locations for NP_201585.1

    Status: REVIEWED

    Source sequence(s)
    AB053259, BG772483
    Consensus CDS
    CCDS8681.1
    UniProtKB/Swiss-Prot
    Q96KX2
    UniProtKB/TrEMBL
    A0A140VKF6
    Related
    ENSP00000326238.3, ENST00000317658.5
    Conserved Domains (1) summary
    pfam01267
    Location:12274
    F-actin_cap_A; F-actin capping protein alpha subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    18738119..18739188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center