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dnaEC DNA polymerase III (alpha subunit), DnaE3 [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936593, updated on 6-Oct-2023

Summary

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Gene symbol
dnaEC
Gene description
DNA polymerase III (alpha subunit), DnaE3
Locus tag
BSU_29230
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU29230
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Genomic context

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Sequence:
NC_000964.3 (2991269..2994616, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene acetyl-CoA carboxylase (carboxyltransferase alpha subunit) Neighboring gene acetyl-CoA carboxylase (carboxyltransferase beta subunit) Neighboring gene NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic) Neighboring gene membrane protein involved in a sporulation process Neighboring gene protein involved in sporulation Neighboring gene putative sporulation-related conserved protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactions of the Bacillus subtilis DnaE polymerase with replisomal proteins modulate its activity and fidelity. Paschalis V, et al. Open Biol, 2017 Sep. PMID 28878042, Free PMC Article
  2. The replicative polymerases PolC and DnaE are required for theta replication of the Bacillus subtilis plasmid pBS72. Titok M, et al. Microbiology (Reading), 2006 May. PMID 16622063
  3. Symmetric activity of DNA polymerases at and recruitment of exonuclease ExoR and of PolA to the Bacillus subtilis replication forks. Hernández-Tamayo R, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31251806, Free PMC Article
  4. Bacillus subtilis DNA polymerases, PolC and DnaE, are required for both leading and lagging strand synthesis in SPP1 origin-dependent DNA replication. Seco EM, et al. Nucleic Acids Res, 2017 Aug 21. PMID 28575448, Free PMC Article
  5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Symmetric activity of DNA polymerases at and recruitment of exonuclease ExoR and of PolA to the Bacillus subtilis replication forks has been reported.
    Title: Symmetric activity of DNA polymerases at and recruitment of exonuclease ExoR and of PolA to the Bacillus subtilis replication forks.
  2. The data show that protein-protein interactions within the replisome modulate the activity and fidelity of DnaE, and confirm the prominent role of DnaE during B. subtilis replication.
    Title: Interactions of the Bacillus subtilis DnaE polymerase with replisomal proteins modulate its activity and fidelity.
  3. Data Data show that DnaG stimulates PolC, but inhibits DnaE.
    Title: Bacillus subtilis DNA polymerases, PolC and DnaE, are required for both leading and lagging strand synthesis in SPP1 origin-dependent DNA replication.
  4. As the mechanism of initiation of the three genomes is substantially different, this suggests that both type C polymerases might be required in any Cairns replication in B. subtilis and presumably in other bacteria encoding PolC and DnaE.
    Title: The replicative polymerases PolC and DnaE are required for theta replication of the Bacillus subtilis plasmid pBS72.
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General gene information

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Homology

General protein information

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Preferred Names
DNA polymerase III (alpha subunit), DnaE3
NP_390801.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    2991269..2994616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_390801.1 DNA polymerase III (alpha subunit), DnaE3 [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_390801.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1KX78
    Conserved Domains (1) summary
    PRK06920
    Location:1 → 1113
    dnaE; DNA polymerase III subunit alpha
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O34623.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases