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cwlO secreted cell wall DL-endopeptidase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936533, updated on 6-Oct-2023

Summary

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Gene symbol
cwlO
Gene description
secreted cell wall DL-endopeptidase
Locus tag
BSU_34800
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU34800
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Genomic context

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Sequence:
NC_000964.3 (3574363..3575784, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative triphosphate pyrophosphate hydrolase Neighboring gene thioredoxin reductase Neighboring gene hypothetical protein Neighboring gene efflux transporter (ATP-binding and permease protein)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deletion of the cell wall peptidoglycan hydrolase gene cwlO or lytE severely impairs transformation efficiency in Bacillus subtilis. Liu TY, et al. J Gen Appl Microbiol, 2018 Jul 23. PMID 29553055
  2. Synthetic lethality of the lytE cwlO genotype in Bacillus subtilis is caused by lack of D,L-endopeptidase activity at the lateral cell wall. Hashimoto M, et al. J Bacteriol, 2012 Feb. PMID 22139507, Free PMC Article
  3. Differentiated roles for MreB-actin isologues and autolytic enzymes in Bacillus subtilis morphogenesis. Domínguez-Cuevas P, et al. Mol Microbiol, 2013 Sep. PMID 23869552, Free PMC Article
  4. A highly unstable transcript makes CwlO D,L-endopeptidase expression responsive to growth conditions in Bacillus subtilis. Noone D, et al. J Bacteriol, 2014 Jan. PMID 24163346, Free PMC Article
  5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cell wall peptidoglycan hydrolase gene cwlO is required for competence development in Bacillus subtilis.
    Title: Deletion of the cell wall peptidoglycan hydrolase gene cwlO or lytE severely impairs transformation efficiency in Bacillus subtilis.
  2. Here authors show that activity of CwlO is regulated by an ABC transporter, FtsEX, which is required for cell elongation, unlike cell division as in Escherichia coli.
    Title: Differentiated roles for MreB-actin isologues and autolytic enzymes in Bacillus subtilis morphogenesis.
  3. The cwlO transcript is very unstable, with its degradation initiated by RNase Y cleavage within the 187-nucleotide leader sequence.
    Title: A highly unstable transcript makes CwlO D,L-endopeptidase expression responsive to growth conditions in Bacillus subtilis.
  4. Endopeptidase activity of LytE or CwlO is essential for cell proliferation. These results strongly suggest that LytE and CwlO are involved in cell elongation and support the inside-to-outside model for peptidoglycan sacculus formation.
    Title: Synthetic lethality of the lytE cwlO genotype in Bacillus subtilis is caused by lack of D,L-endopeptidase activity at the lateral cell wall.
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General gene information

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Homology

General protein information

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Preferred Names
secreted cell wall DL-endopeptidase
NP_391360.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    3574363..3575784 complement
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_391360.1 secreted cell wall DL-endopeptidase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_391360.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1KRE4
    Conserved Domains (2) summary
    COG3883
    Location:1 → 290
    CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
    pfam00877
    Location:358 → 469
    NLPC_P60; NlpC/P60 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40767.2

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials