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codY transcriptional regulator, GTP and BCAA-dependent [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936491, updated on 10-Feb-2026
Gene symbol
codY
Gene description
transcriptional regulator, GTP and BCAA-dependent
Locus tag
BSU_16170
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU16170
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Sequence:
NC_000964.3 (1690119..1690898)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene two-component ATP-dependent protease (N-terminal serine protease) Neighboring gene two-component ATP-dependent protease (ATPase and chaperone) Neighboring gene flagellar component of cell-proximal portion of basal-body rod Neighboring gene flagellar component of cell-proximal portion of basal-body rod

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. CodY, a master integrator of metabolism and virulence in Gram-positive bacteria. Brinsmade SR. Curr Genet, 2017 Jun. PMID 27744611
  2. A region of Bacillus subtilis CodY protein required for interaction with DNA. Joseph P, et al. J Bacteriol, 2005 Jun. PMID 15937175, Free PMC Article
  3. Interaction of Bacillus subtilis CodY with GTP. Handke LD, et al. J Bacteriol, 2008 Feb. PMID 17993518, Free PMC Article
  4. Genetic and biochemical analysis of CodY-binding sites in Bacillus subtilis. Belitsky BR, et al. J Bacteriol, 2008 Feb. PMID 18083814, Free PMC Article
  5. Genetic and biochemical analysis of the interaction of Bacillus subtilis CodY with branched-chain amino acids. Villapakkam AC, et al. J Bacteriol, 2009 Nov. PMID 19749041, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a comparison between wild-type B. subtilis and codY null mutant cells failed to reveal a role for CodY in regulating the braB gene, coding for a branched-chain amino acid permease
    Title: CodY, a master integrator of metabolism and virulence in Gram-positive bacteria.
  2. The increase in BraB expression only at intermediate activities of CodY may facilitate the uptake of BCAA when they are not in excess but prevent unneeded BraB synthesis when other BCAA transporters are active
    Title: Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB.
  3. Study shows that CcpA forms complexes with CodY and RpoA in Bacillus subtilis.
    Title: CcpA forms complexes with CodY and RpoA in Bacillus subtilis.
  4. Guanine derivative, most likely GTP, controls CodY activity.
    Title: Dissecting complex metabolic integration provides direct genetic evidence for CodY activation by guanine nucleotides.
  5. Changes in the rate of endogenous isoleucine, leucine and valine (ILV) synthesis serve as an important signal for CodY-mediated gene regulation.
    Title: Regulation of CodY activity through modulation of intracellular branched-chain amino acid pools.
  6. Results indicate that the transition state regulator ScoC, together with CodY and AbrB, negatively regulates bacilysin production in B. subtilis. [ScoC]
    Title: ScoC regulates bacilysin production at the transcription level in Bacillus subtilis.
  7. Binding studies with branched-chain amino acids and their analogs revealed that an amino group at position 2 and a methyl group at position 3 of valine are critical components of the recognition of the amino acids by CodY.
    Title: Genetic and biochemical analysis of the interaction of Bacillus subtilis CodY with branched-chain amino acids.
  8. Results show that versions of the AATTTTCWGAAAATT motif, first identified for Lactococcus lactis CodY, with up to five mismatches play an important role in the interaction of B. subtilis CodY with DNA.
    Title: Genetic and biochemical analysis of CodY-binding sites in Bacillus subtilis.
  9. Interaction of CodY with GTP is specific and results in increased affinity for its target genes.
    Title: Interaction of Bacillus subtilis CodY with GTP.
  10. Transcription of the acetate kinase gene (ackA) proved to be activated a global regulatory protein, CodY.
    Title: Positive regulation of Bacillus subtilis ackA by CodY and CcpA: establishing a potential hierarchy in carbon flow.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Homology

Preferred Names
transcriptional regulator, GTP and BCAA-dependent
NP_389499.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_389499.1 transcriptional regulator, GTP and BCAA-dependent [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_389499.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1JJD3, A0AC61YWJ6
    Conserved Domains (1) summary
    PRK04158
    Location:1 → 254
    PRK04158; GTP-sensing pleiotropic transcriptional regulator CodY
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39779.3

Gene LinkOut

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Other Literature Sources
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Research Materials