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mecA adaptor protein controlling oligomerization of the AAA+ protein ClpC [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936406, updated on 12-Feb-2021

Summary

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Gene symbol
mecA
Gene description
adaptor protein controlling oligomerization of the AAA+ protein ClpC
Locus tag
BSU_11520
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU11520
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Genomic context

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Sequence:
NC_000964.3 (1229068..1229724)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene redox-sensitive regulator Neighboring gene putative membrane protein of unknown function Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene protein involved in establishment of DNA transport in competence Neighboring gene oligoendopeptidase F

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MecA dampens transitions to spore, biofilm exopolysaccharide and competence expression by two different mechanisms. Prepiak P, et al. Mol Microbiol, 2011 May. PMID 21435029, Free PMC Article
  2. Crystal structure of the MecA degradation tag. Wang F, et al. J Biol Chem, 2009 Dec 4. PMID 19801546, Free PMC Article
  3. ClpC and MecA, components of a proteolytic machine, prevent Spo0A-P-dependent transcription without degradation. Tanner AW, et al. Mol Microbiol, 2018 Apr. PMID 29446505, Free PMC Article
  4. Molecular determinants of MecA as a degradation tag for the ClpCP protease. Mei Z, et al. J Biol Chem, 2009 Dec 4. PMID 19767395, Free PMC Article
  5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MecA inhibits the transcription of several Spo0A-P activated genes, but fails to de-repress several Spo0A-P repressed promoters.
    Title: ClpC and MecA, components of a proteolytic machine, prevent Spo0A-P-dependent transcription without degradation.
  2. MecA downregulates eps expression and spore formation by directly interacting with Spo0A. MecA does not target Spo0A for degradation. It inhibits the transcriptional activity of Spo0A~P by direct binding.
    Title: MecA dampens transitions to spore, biofilm exopolysaccharide and competence expression by two different mechanisms.
  3. analysis of the crystal structure of the MecA degradation tag
    Title: Crystal structure of the MecA degradation tag.
  4. ClpCP protease undergoes dynamic cycles of assembly and disassembly, which are triggered by association with MecA and the degradation of MecA, respectively
    Title: Molecular determinants of MecA as a degradation tag for the ClpCP protease.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
adaptor protein controlling oligomerization of the AAA+ protein ClpC
NP_389034.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_389034.1 adaptor protein controlling oligomerization of the AAA+ protein ClpC [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_389034.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P37958
    Conserved Domains (1) summary
    PRK02315
    Location:1 → 218
    PRK02315; adaptor protein MecA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3J3R_1.1
3J3R_2.1
3J3R_3.1
3J3R_4.1
3J3R_5.1
3J3R_6.1
3J3S_1.1
3J3S_2.1
3J3S_3.1
3J3S_4.1
3J3S_5.1
3J3S_6.1
3J3T_1.1
3J3T_2.1
3J3T_3.1
3J3T_4.1
3J3T_5.1
3J3T_6.1
3J3U_1.1
3J3U_2.1
3J3U_3.1
3J3U_4.1
3J3U_5.1
3J3U_6.1
P37958.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases