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RAB33A RAB33A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 9363, updated on 12-Oct-2019


Official Symbol
RAB33Aprovided by HGNC
Official Full Name
RAB33A, member RAS oncogene familyprovided by HGNC
Primary source
See related
Ensembl:ENSG00000134594 MIM:300333
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is GTP-binding protein and may be involved in vesicle transport. [provided by RefSeq, Jul 2008]
Biased expression in brain (RPKM 10.9), lymph node (RPKM 3.6) and 7 other tissues See more

Genomic context

See RAB33A in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (130110633..130184873)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129305773..129318844)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373335 Neighboring gene UTP14A small subunit processome component Neighboring gene BCL6 corepressor like 1 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene apoptosis inducing factor mitochondria associated 1 Neighboring gene zinc finger protein 280C Neighboring gene RNA, U6 small nuclear 1130, pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • RAB geranylgeranylation, organism-specific biosystem (from REACTOME)
    RAB geranylgeranylation, organism-specific biosystemHuman cells have more than 60 RAB proteins that are involved in trafficking of proteins in the endolysosomal system. These small GTPases contribute to trafficking specificity by localizing to the mem...
  • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
    TBC/RABGAPs, organism-specific biosystemRab GTPases are peripheral membrane proteins involved in membrane trafficking. Often through their indirect interactions with coat components, motors, tethering factors and SNAREs, the Rab GTPases se...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • MGC1488

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
plasma membrane IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
ras-related protein Rab-33A
Small GTP-binding protein S10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_012558.1 RefSeqGene

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004794.3NP_004785.1  ras-related protein Rab-33A

    See identical proteins and their annotated locations for NP_004785.1

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    ENSP00000257017.4, ENST00000257017.5
    Conserved Domains (1) summary
    Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029963.2XP_016885452.1  ras-related protein Rab-33A isoform X1

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