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TADA2B transcriptional adaptor 2B [ Homo sapiens (human) ]

Gene ID: 93624, updated on 5-Mar-2024

Summary

Official Symbol
TADA2Bprovided by HGNC
Official Full Name
transcriptional adaptor 2Bprovided by HGNC
Primary source
HGNC:HGNC:30781
See related
Ensembl:ENSG00000173011 MIM:608790; AllianceGenome:HGNC:30781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADA2B; ADA2(beta)
Summary
TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See TADA2B in Genome Data Viewer
Location:
4p16.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (7043372..7057952)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (7015207..7029792)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (7045099..7059679)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 14 Neighboring gene RN7SK pseudogene 292 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:7009000-7009638 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:7009639-7010278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7017555-7018058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7018059-7018562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7023455-7024032 Neighboring gene uncharacterized LOC100129931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7048917-7049418 Neighboring gene cilia and flagella associated protein 184 Neighboring gene uncharacterized LOC105374368 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:7067016-7067117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15249 Neighboring gene uncharacterized LOC105374370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21274 Neighboring gene GrpE like 1, mitochondrial Neighboring gene long intergenic non-protein coding RNA 2447

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC21874

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SAGA-type complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SAGA-type complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
transcriptional adapter 2-beta
Names
ADA2-beta
ADA2-like protein beta
transcriptional adaptor 2 (ADA2 homolog, yeast)-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152293.3NP_689506.2  transcriptional adapter 2-beta

    See identical proteins and their annotated locations for NP_689506.2

    Status: VALIDATED

    Source sequence(s)
    AC097382, AK093974, BC047794
    Consensus CDS
    CCDS47007.1
    UniProtKB/Swiss-Prot
    A0AUJ8, A4QMR7, B3KSN0, B3KU86, Q6MZG9, Q86TJ2
    Related
    ENSP00000308022.6, ENST00000310074.8
    Conserved Domains (1) summary
    COG5114
    Location:6415
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    7043372..7057952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    7015207..7029792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)