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MRFAP1 Morf4 family associated protein 1 [ Homo sapiens (human) ]

Gene ID: 93621, updated on 23-Nov-2021

Summary

Official Symbol
MRFAP1provided by HGNC
Official Full Name
Morf4 family associated protein 1provided by HGNC
Primary source
HGNC:HGNC:24549
See related
Ensembl:ENSG00000179010 MIM:616905
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR1; PAM14
Summary
This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in brain (RPKM 146.3), adrenal (RPKM 117.0) and 25 other tissues See more
Orthologs
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Genomic context

See MRFAP1 in Genome Data Viewer
Location:
4p16.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (6640685..6642729)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (6642412..6644456)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374365 Neighboring gene mannosidase alpha class 2B member 2 Neighboring gene long intergenic non-protein coding RNA 2482 Neighboring gene Morf4 family associated protein 1 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MORF4 family-associated protein 1
Names
Mof4 family associated protein 1
T-cell activation protein
protein associated with MRG of 14 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272053.2NP_001258982.1  MORF4 family-associated protein 1 isoform a

    See identical proteins and their annotated locations for NP_001258982.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AK123360, BG255189
    Consensus CDS
    CCDS3389.1
    UniProtKB/Swiss-Prot
    Q9Y605
    Related
    ENSP00000318352.4, ENST00000320912.8
    Conserved Domains (1) summary
    pfam15155
    Location:1127
    MRFAP1; MORF4 family-associated protein1
  2. NM_033296.3NP_150638.1  MORF4 family-associated protein 1 isoform a

    See identical proteins and their annotated locations for NP_150638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AK074496, AK123360, BG255189
    Consensus CDS
    CCDS3389.1
    UniProtKB/Swiss-Prot
    Q9Y605
    UniProtKB/TrEMBL
    B3KQA0
    Related
    ENSP00000372024.4, ENST00000382581.5
    Conserved Domains (1) summary
    pfam15155
    Location:1127
    MRFAP1; MORF4 family-associated protein1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    6640685..6642729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001272054.1: Suppressed sequence

    Description
    NM_001272054.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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