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padR transcriptional regulator of phenolic acid decarboxylase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936174, updated on 6-Oct-2023
Gene symbol
padR
Gene description
transcriptional regulator of phenolic acid decarboxylase
Locus tag
BSU_08340
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU08340
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Sequence:
NC_000964.3 (909198..909746, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene ABC transporter (permease) biofilm formation Neighboring gene ABC transporter (permease) biofilm formation Neighboring gene secreted esterase / acylglycerol lipase Neighboring gene acetyl-glucosamine metabolite exporter component involved in biofilm formation

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural basis of effector and operator recognition by the phenolic acid-responsive transcriptional regulator PadR. Park SC, et al. Nucleic Acids Res, 2017 Dec 15. PMID 29136175, Free PMC Article
  2. Genetic and biochemical analysis of PadR-padC promoter interactions during the phenolic acid stress response in Bacillus subtilis 168. Nguyen TK, et al. J Bacteriol, 2011 Aug. PMID 21685295, Free PMC Article
  3. Phenolic acid-mediated regulation of the padC gene, encoding the phenolic acid decarboxylase of Bacillus subtilis. Tran NP, et al. J Bacteriol, 2008 May. PMID 18326577, Free PMC Article
  4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PadR directly binds a phenolic acid effector molecule using a unique interdomain pocket created between the N-terminal winged helix-turn-helix (wHTH) domain (NTD) and a C-terminal homodimerization domain (CTD).
    Title: Structural basis of effector and operator recognition by the phenolic acid-responsive transcriptional regulator PadR.
  2. This study reports footprinting assays to identify the region protected by PadR, EMSA with a modified padC promoter to determine the interacting sequences, and mutagenesis of padR to identify residues essential for its function.
    Title: Genetic and biochemical analysis of PadR-padC promoter interactions during the phenolic acid stress response in Bacillus subtilis 168.
  3. PadR, a negative transcriptional regulator of padC expression, was identified.
    Title: Phenolic acid-mediated regulation of the padC gene, encoding the phenolic acid decarboxylase of Bacillus subtilis.
Submit: New GeneRIF Correction

Homology

Preferred Names
transcriptional regulator of phenolic acid decarboxylase
NP_388715.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    909198..909746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_388715.1 transcriptional regulator of phenolic acid decarboxylase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_388715.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1KN95
    Conserved Domains (2) summary
    COG1695
    Location:3 → 126
    PadR; DNA-binding transcriptional regulator, PadR family [Transcription]
    pfam10400
    Location:94 → 180
    Vir_act_alpha_C; Virulence activator alpha C-term
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P94443.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases