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cotA outer spore coat copper-dependent promiscuous laccase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936023, updated on 6-Oct-2023
Gene symbol
cotA
Gene description
outer spore coat copper-dependent promiscuous laccase
Locus tag
BSU_06300
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU06300
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Sequence:
NC_000964.3 (683462..685003, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative aminoacrylate hydrolase Neighboring gene hypothetical protein Neighboring gene gamma-aminobutyrate (GABA) permease; proline permease Neighboring gene hypothetical protein

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Perturbations of the T1 copper site in the CotA laccase from Bacillus subtilis: structural, biochemical, enzymatic and stability studies. Durão P, et al. J Biol Inorg Chem, 2006 Jun. PMID 16680453
  2. Surface Display of Bacterial Laccase CotA on Escherichia coli Cells and its Application in Industrial Dye Decolorization. Zhang Y, et al. Mol Biotechnol, 2018 Sep. PMID 30030754
  3. Localization of proteins to different layers and regions of Bacillus subtilis spore coats. Imamura D, et al. J Bacteriol, 2010 Jan. PMID 19933362, Free PMC Article
  4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Further analyses demonstrated that the fusion protein PgsA/CotA efficiently translocates to the cell surface of E. coli with an enzymatic activity of 65 U/10(8) cells. Surface-displayed CotA was shown to possess improved enzymatic properties compared with those of the wild-type CotA, including higher thermal stability and stronger inhibitor tolerance
    Title: Surface Display of Bacterial Laccase CotA on Escherichia coli Cells and its Application in Industrial Dye Decolorization.
  2. CotA and CotC were more abundant at the mother cell distal pole of the forespore.
    Title: Localization of proteins to different layers and regions of Bacillus subtilis spore coats.
  3. The T1 copper centre clearly plays a key role, from the structural, catalytic and stability viewpoints, in the regulation of CotA laccase activity.
    Title: Perturbations of the T1 copper site in the CotA laccase from Bacillus subtilis: structural, biochemical, enzymatic and stability studies.
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Homology

Preferred Names
outer spore coat copper-dependent promiscuous laccase
NP_388511.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    683462..685003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_388511.1 outer spore coat copper-dependent promiscuous laccase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_388511.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A348FKE9
    Conserved Domains (1) summary
    COG2132
    Location:8 → 511
    SufI; Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA) [Cell cycle control, cell division, chromosome partitioning, Inorganic ion transport and metabolism, Cell wall/membrane/envelope biogenes
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
4Q89_A.1
4Q89_B.1
4Q8B_A.1
4Q8B_B.1
4YVN_A.1
4YVU_A.1
5ZLJ_A.1
P07788.4

Gene LinkOut

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Other Literature Sources
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Research Materials