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PPIG peptidylprolyl isomerase G [ Homo sapiens (human) ]

Gene ID: 9360, updated on 12-Oct-2019

Summary

Official Symbol
PPIGprovided by HGNC
Official Full Name
peptidylprolyl isomerase Gprovided by HGNC
Primary source
HGNC:HGNC:14650
See related
Ensembl:ENSG00000138398 MIM:606093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYP; SRCyp; SCAF10; CARS-Cyp
Expression
Ubiquitous expression in thyroid (RPKM 12.9), endometrium (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See PPIG in Genome Data Viewer
Location:
2q31.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (169584343..169641406)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170440850..170497916)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene kelch like family member 41 Neighboring gene FAST kinase domains 1 Neighboring gene family with sequence similarity 49 member B pseudogene Neighboring gene coiled-coil domain containing 173 Neighboring gene PHOSPHO2-KLHL23 readthrough Neighboring gene phosphatase, orphan 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of peptidylprolyl isomerase G (PPIG, cyclophilin G) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133241

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA splicing TAS
Traceable Author Statement
more info
PubMed 
protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase G
Names
CARS-cyclophilin
CASP10
Clk-associating RS-cyclophilin
PPIase G
SR-cyclophilin
SR-cyp
SR-related CTD-associated factor 10
cyclophilin G
peptidyl-prolyl isomerase G (cyclophilin G)
rotamase G
NP_004783.2
XP_005247023.1
XP_005247024.1
XP_016860791.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004792.3NP_004783.2  peptidyl-prolyl cis-trans isomerase G

    See identical proteins and their annotated locations for NP_004783.2

    Status: VALIDATED

    Source sequence(s)
    AC016772, BG615922, CA418130, X99717
    Consensus CDS
    CCDS2235.1
    UniProtKB/Swiss-Prot
    Q13427
    Related
    ENSP00000260970.3, ENST00000260970.8
    Conserved Domains (1) summary
    cl00197
    Location:8175
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    169584343..169641406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246967.1XP_005247024.1  peptidyl-prolyl cis-trans isomerase G isoform X1

    See identical proteins and their annotated locations for XP_005247024.1

    UniProtKB/Swiss-Prot
    Q13427
    Related
    ENSP00000407083.2, ENST00000448752.6
    Conserved Domains (1) summary
    cl00197
    Location:8175
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  2. XM_017005302.2XP_016860791.1  peptidyl-prolyl cis-trans isomerase G isoform X2

    Related
    ENSP00000402222.1, ENST00000414307.5
  3. XM_005246966.2XP_005247023.1  peptidyl-prolyl cis-trans isomerase G isoform X1

    See identical proteins and their annotated locations for XP_005247023.1

    UniProtKB/Swiss-Prot
    Q13427
    Conserved Domains (1) summary
    cl00197
    Location:8175
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
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