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ccpA transcriptional regulator of catabolite repression (Lacl family) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 935942, updated on 12-Feb-2021
Gene symbol
ccpA
Gene description
transcriptional regulator of catabolite repression (Lacl family)
Locus tag
BSU_29740
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU29740
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Sequence:
NC_000964.3 (3044165..3045169, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene component of the acetyl-coenzyme A synthetase regulation pathway Neighboring gene protein deacetylase (regulates AcsA activity) Neighboring gene sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation Neighboring gene sodium channel stator-force generator subunit of flagellar rotation Neighboring gene bifunctional chorismate mutase type II-isozyme 3 (regulatory domain); 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase Neighboring gene bacilliredoxin involved in debacillithiolation

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Evidence that Bacillus catabolite control protein CcpA interacts with RNA polymerase to inhibit transcription. Kim JH, et al. Mol Microbiol, 2005 Apr. PMID 15773986
  2. Structural analysis of B. subtilis CcpA effector binding site. Chaptal V, et al. Proteins, 2006 Aug 15. PMID 16755587
  3. Bacillus subtilis ilvB operon: an intersection of global regulons. Shivers RP, et al. Mol Microbiol, 2005 Jun. PMID 15916605
  4. CcpA forms complexes with CodY and RpoA in Bacillus subtilis. Wünsche A, et al. FEBS J, 2012 Jun. PMID 22512862
  5. Quantitative interdependence of coeffectors, CcpA and cre in carbon catabolite regulation of Bacillus subtilis. Seidel G, et al. FEBS J, 2005 May. PMID 15885105

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thus, degU is induced through activation of autoregulation by a decrease in ClpCP-dependent proteolysis of DegU-P.
    Title: The Bacillus subtilis response regulator gene degU is positively regulated by CcpA and by catabolite-repressed synthesis of ClpC.
  2. Study shows that CcpA forms complexes with CodY and RpoA in Bacillus subtilis.
    Title: CcpA forms complexes with CodY and RpoA in Bacillus subtilis.
  3. The catabolite repression by malate is exerted by the CcpA-HPrK complex.
    Title: Malate-mediated carbon catabolite repression in Bacillus subtilis involves the HPrK/CcpA pathway.
  4. Phosphorylation of Ser46 of HPr or of the homologous Crh protein by HPr kinase and formation of a repressor complex with CcpA are parts of the B. subtilis carbon catabolite repression system.
    Title: Characterization of a mannose utilization system in Bacillus subtilis.
  5. ccpA regulates ackA expression
    Title: Positive regulation of Bacillus subtilis ackA by CodY and CcpA: establishing a potential hierarchy in carbon flow.
  6. The carbon control protein-A (CcpA) of Bacillus subtilis, primarily concerned with carbon metabolism, influences expression of phosphorus (pho) regulon genes, alkaline phosphatase structural genes, phoA and phoB.
    Title: Regulation of pho regulon gene expression by the carbon control protein A, CcpA, in Bacillus subtilis.
  7. interacts with RNA polymerase to inhibit transcription.
    Title: Evidence that Bacillus catabolite control protein CcpA interacts with RNA polymerase to inhibit transcription.
  8. Transcription of the citST operon was repressed in the presence of glucose by the general transcription factor CcpA.
    Title: Catabolite repression of the citST two-component system in Bacillus subtilis.
  9. Data suggest specific roles for fructose-1,6-bisphosphate and glucose-6-phosphate in enhancing HPrSerP-, but not CrhP-mediated carbon catabolite regulation through CcpA.
    Title: Quantitative interdependence of coeffectors, CcpA and cre in carbon catabolite regulation of Bacillus subtilis.
  10. involved in transcription regulation of ilv-leu operon together with CodY and TnrA regulators of cellular catabolic and anabolic genes.
    Title: Elaborate transcription regulation of the Bacillus subtilis ilv-leu operon involved in the biosynthesis of branched-chain amino acids through global regulators of CcpA, CodY and TnrA.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Homology

Preferred Names
transcriptional regulator of catabolite repression (Lacl family)
NP_390852.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    3044165..3045169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_390852.1 transcriptional regulator of catabolite repression (Lacl family) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_390852.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P25144
    Conserved Domains (1) summary
    TIGR01481
    Location:3 → 333
    ccpA; catabolite control protein A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25144.1

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