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TRMT10A tRNA methyltransferase 10A [ Homo sapiens (human) ]

Gene ID: 93587, updated on 6-Nov-2019

Summary

Official Symbol
TRMT10Aprovided by HGNC
Official Full Name
tRNA methyltransferase 10Aprovided by HGNC
Primary source
HGNC:HGNC:28403
See related
Ensembl:ENSG00000145331 MIM:616013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSSGM; TRM10; MSSGM1; RG9MTD2; HEL-S-88
Summary
This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in testis (RPKM 4.1), thyroid (RPKM 2.7) and 25 other tissues See more
Orthologs

Genomic context

See TRMT10A in Genome Data Viewer
Location:
4q23
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (99546709..99564039, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (100467864..100485189, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ADH7 promoter Neighboring gene alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Neighboring gene chromosome 4 open reading frame 17 Neighboring gene microsomal triglyceride transfer protein Neighboring gene chromosome 4 open reading frame 54

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • tRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
    tRNA modification in the nucleus and cytosol, organism-specific biosystemAt least 92 distinct tRNA nucleotide base modifications have been found. The modifications are made post-transcriptionally by a large group of disparate enzymes located in the nucleus, cytosol, and m...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20325, MGC27034

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
tRNA (guanine(9)-N(1))-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (guanine-N1-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA (guanine-N1-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mitochondrial tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tRNA methyltransferase 10 homolog A
Names
RNA (guanine-9-)-methyltransferase domain-containing protein 2
epididymis secretory protein Li 88
tRNA (guanine(9)-N(1))-methyltransferase TRMT10A
NP_001128137.1
NP_001128138.1
NP_689505.1
XP_005263409.1
XP_006714480.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041774.1 RefSeqGene

    Range
    5019..22347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134665.3NP_001128137.1  tRNA methyltransferase 10 homolog A isoform 1

    See identical proteins and their annotated locations for NP_001128137.1

    Status: REVIEWED

    Source sequence(s)
    AC083902, AK313548, AW242551, BC028373, DB455183
    Consensus CDS
    CCDS3650.1
    UniProtKB/Swiss-Prot
    Q8TBZ6
    UniProtKB/TrEMBL
    V9HVY8
    Related
    ENSP00000378342.2, ENST00000394876.7
    Conserved Domains (1) summary
    cl00407
    Location:112276
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  2. NM_001134666.3NP_001128138.1  tRNA methyltransferase 10 homolog A isoform 1

    See identical proteins and their annotated locations for NP_001128138.1

    Status: REVIEWED

    Source sequence(s)
    AC083902, AK000332, AW242551, BC028373, DB455183
    Consensus CDS
    CCDS3650.1
    UniProtKB/Swiss-Prot
    Q8TBZ6
    UniProtKB/TrEMBL
    V9HVY8
    Related
    ENSP00000378343.3, ENST00000394877.7
    Conserved Domains (1) summary
    cl00407
    Location:112276
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  3. NM_001375880.1NP_001362809.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC083902
  4. NM_001375881.1NP_001362810.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC083902
  5. NM_001375882.1NP_001362811.1  tRNA methyltransferase 10 homolog A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC083902
  6. NM_152292.5NP_689505.1  tRNA methyltransferase 10 homolog A isoform 1

    See identical proteins and their annotated locations for NP_689505.1

    Status: REVIEWED

    Source sequence(s)
    AC083902, AW242551, BC028373
    Consensus CDS
    CCDS3650.1
    UniProtKB/Swiss-Prot
    Q8TBZ6
    UniProtKB/TrEMBL
    V9HVY8
    Related
    ENSP00000273962.3, ENST00000273962.7
    Conserved Domains (1) summary
    cl00407
    Location:112276
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    99546709..99564039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714417.2XP_006714480.1  tRNA methyltransferase 10 homolog A isoform X1

    UniProtKB/Swiss-Prot
    Q8TBZ6
    UniProtKB/TrEMBL
    V9HVY8
    Conserved Domains (1) summary
    cl00407
    Location:112276
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  2. XM_005263352.3XP_005263409.1  tRNA methyltransferase 10 homolog A isoform X1

    UniProtKB/Swiss-Prot
    Q8TBZ6
    UniProtKB/TrEMBL
    V9HVY8
    Conserved Domains (1) summary
    cl00407
    Location:112276
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
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