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SLC22A6 solute carrier family 22 member 6 [ Homo sapiens (human) ]

Gene ID: 9356, updated on 21-Dec-2019

Summary

Official Symbol
SLC22A6provided by HGNC
Official Full Name
solute carrier family 22 member 6provided by HGNC
Primary source
HGNC:HGNC:10970
See related
Ensembl:ENSG00000197901 MIM:607582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OAT1; PAHT; HOAT1; ROAT1
Summary
The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward kidney (RPKM 150.9) See more
Orthologs

Genomic context

See SLC22A6 in Genome Data Viewer
Location:
11q12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62976597..62984967, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62744069..62752495, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369333 Neighboring gene cholinergic receptor muscarinic 1 Neighboring gene RNA, 7SL, cytoplasmic 259, pseudogene Neighboring gene solute carrier family 22 member 8 Neighboring gene PTTG1 regulator of sister chromatid separation, securin pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ55736, MGC45260

Gene Ontology Provided by GOA

Function Evidence Code Pubs
anion:anion antiporter activity IEA
Inferred from Electronic Annotation
more info
 
chloride ion binding IEA
Inferred from Electronic Annotation
more info
 
inorganic anion exchanger activity IDA
Inferred from Direct Assay
more info
PubMed 
organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
organic anion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
alpha-ketoglutarate transport IDA
Inferred from Direct Assay
more info
PubMed 
anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organic anion transport IDA
Inferred from Direct Assay
more info
PubMed 
organic anion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
renal tubular secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal tubular secretion NAS
Non-traceable Author Statement
more info
PubMed 
response to methotrexate IEA
Inferred from Electronic Annotation
more info
 
sodium-independent organic anion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
caveola IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 22 member 6
Names
PAH transporter
hPAHT
hROAT1
organic anion transporter 1
para-aminohippurate transporter
renal organic anion transporter 1
solute carrier family 22 (organic anion transporter), member 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004790.5NP_004781.2  solute carrier family 22 member 6 isoform a

    See identical proteins and their annotated locations for NP_004781.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also called hOAT1-1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB009697, AI017670, DA629600
    Consensus CDS
    CCDS31591.1
    UniProtKB/Swiss-Prot
    Q4U2R8
    Related
    ENSP00000367102.3, ENST00000377871.7
    Conserved Domains (2) summary
    cd06174
    Location:135505
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11515
    2A0119; cation transport protein
  2. NM_153276.3NP_695008.1  solute carrier family 22 member 6 isoform b

    See identical proteins and their annotated locations for NP_695008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also called OAT1-2) lacks an alternate in-frame segment compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    BC033682
    Consensus CDS
    CCDS8041.1
    UniProtKB/Swiss-Prot
    Q4U2R8
    Related
    ENSP00000353597.4, ENST00000360421.8
    Conserved Domains (1) summary
    TIGR00898
    Location:11515
    2A0119; cation transport protein
  3. NM_153277.3NP_695009.1  solute carrier family 22 member 6 isoform c

    See identical proteins and their annotated locations for NP_695009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also called OAT1-3) lacks two alternate in-frame segments compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
    Source sequence(s)
    AI017670, AJ251529, DA628191, DB320467
    Consensus CDS
    CCDS44632.1
    UniProtKB/Swiss-Prot
    Q4U2R8
    Related
    ENSP00000396401.2, ENST00000458333.6
    Conserved Domains (2) summary
    cd06174
    Location:135456
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11471
    2A0119; cation transport protein
  4. NM_153278.3NP_695010.1  solute carrier family 22 member 6 isoform d

    See identical proteins and their annotated locations for NP_695010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also called OAT1-4) lacks an alternate in-frame segment compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.
    Source sequence(s)
    AB009697, AI017670, AJ271205, DA628191
    Consensus CDS
    CCDS44631.1
    UniProtKB/Swiss-Prot
    Q4U2R8
    Related
    ENSP00000404441.2, ENST00000421062.2
    Conserved Domains (2) summary
    cd06174
    Location:135456
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11471
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62976597..62984967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018562.2XP_016874051.1  solute carrier family 22 member 6 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153279.1: Suppressed sequence

    Description
    NM_153279.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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