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CER1 cerberus 1, DAN family BMP antagonist [ Homo sapiens (human) ]

Gene ID: 9350, updated on 1-Jun-2020

Summary

Official Symbol
CER1provided by HGNC
Official Full Name
cerberus 1, DAN family BMP antagonistprovided by HGNC
Primary source
HGNC:HGNC:1862
See related
Ensembl:ENSG00000147869 MIM:603777
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAND4
Summary
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CER1 in Genome Data Viewer
Location:
9p22.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (14715082..14724308, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14719731..14722715, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nuclear factor I B Neighboring gene tRNA-His (anticodon GTG) 1-6 Neighboring gene zinc finger DHHC-type palmitoyltransferase 21 Neighboring gene cell division cycle associated 4 pseudogene 1 Neighboring gene uncharacterized LOC105375979 Neighboring gene FRAS1 related extracellular matrix 1 Neighboring gene RNA, U6 small nuclear 1260, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC96951, MGC119894, MGC119895

Gene Ontology Provided by GOA

Function Evidence Code Pubs
BMP binding IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
morphogen activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
morphogen activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
BMP signaling pathway TAS
Traceable Author Statement
more info
 
anterior/posterior axis specification ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
anterior/posterior pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration involved in gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to BMP stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of heart left/right asymmetry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
growth plate cartilage chondrocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of activin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mesoderm development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequestering of BMP in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequestering of BMP in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
sequestering of BMP in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction involved in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction involved in regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ureteric bud development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cerberus
Names
DAN domain family member 4
cerberus 1, cysteine knot superfamily, homolog
cerberus-related 1
cerberus-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005454.3NP_005445.1  cerberus precursor

    See identical proteins and their annotated locations for NP_005445.1

    Status: REVIEWED

    Source sequence(s)
    AF400435, AL390732, BU071333, CD652441
    Consensus CDS
    CCDS6476.1
    UniProtKB/Swiss-Prot
    O95813
    Related
    ENSP00000370297.3, ENST00000380911.4
    Conserved Domains (1) summary
    pfam03045
    Location:144242
    DAN; DAN domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    14715082..14724308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001746419.1 RNA Sequence

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