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CER1 cerberus 1, DAN family BMP antagonist [ Homo sapiens (human) ]

Gene ID: 9350, updated on 8-Jul-2018
Official Symbol
CER1provided by HGNC
Official Full Name
cerberus 1, DAN family BMP antagonistprovided by HGNC
Primary source
HGNC:HGNC:1862
See related
Ensembl:ENSG00000147869 MIM:603777; Vega:OTTHUMG00000021022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAND4
Summary
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
See CER1 in Genome Data Viewer
Location:
9p22.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (14715082..14724308, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14719731..14722715, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene transfer RNA-His (GTG) 1-6 Neighboring gene zinc finger DHHC-type containing 21 Neighboring gene cell division cycle associated 4 pseudogene 1 Neighboring gene FRAS1 related extracellular matrix 1 Neighboring gene uncharacterized LOC105375979 Neighboring gene RNA, U6 small nuclear 1260, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • BMP receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    BMP receptor signaling, organism-specific biosystem
    BMP receptor signaling
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
  • Regulation of signaling by NODAL, organism-specific biosystem (from REACTOME)
    Regulation of signaling by NODAL, organism-specific biosystemMature NODAL can form heterodimers with LEFTY1, LEFTY2, or CERBERUS. The heterodimers do not activate the NODAL receptor. LEFTY1 and LEFTY2 also bind CRIPTO and CRYPTIC coreceptors and prevent them f...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by BMP, organism-specific biosystem (from REACTOME)
    Signaling by BMP, organism-specific biosystemBone morphogenetic proteins (BMPs) have many biological activities in various tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung. They are members of the Transf...
  • Signaling by NODAL, organism-specific biosystem (from REACTOME)
    Signaling by NODAL, organism-specific biosystemSignaling by NODAL is essential for patterning of the axes of the embryo and formation of mesoderm and endoderm (reviewed in Schier 2009, Shen 2007). The NODAL proprotein is secreted and cleaved extr...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC96951, MGC119894, MGC119895

Gene Ontology Provided by GOA

Function Evidence Code Pubs
BMP binding IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
morphogen activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
morphogen activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
BMP signaling pathway TAS
Traceable Author Statement
more info
 
anterior/posterior axis specification ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
anterior/posterior pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration involved in gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to BMP stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of heart left/right asymmetry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
growth plate cartilage chondrocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of activin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mesoderm development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
sequestering of BMP in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequestering of BMP in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
sequestering of BMP in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction involved in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction involved in regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ureteric bud development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
cerberus
Names
DAN domain family member 4
cerberus 1, cysteine knot superfamily, homolog
cerberus-related 1
cerberus-related protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005454.2NP_005445.1  cerberus precursor

    See identical proteins and their annotated locations for NP_005445.1

    Status: REVIEWED

    Source sequence(s)
    AF400435, BU071333, CD652441
    Consensus CDS
    CCDS6476.1
    UniProtKB/Swiss-Prot
    O95813
    Related
    ENSP00000370297.3, OTTHUMP00000022757, ENST00000380911.3, OTTHUMT00000055453
    Conserved Domains (1) summary
    pfam03045
    Location:144242
    DAN; DAN domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    14715082..14724308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001746419.1 RNA Sequence

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