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NDST3 N-deacetylase and N-sulfotransferase 3 [ Homo sapiens (human) ]

Gene ID: 9348, updated on 11-Jun-2021

Summary

Official Symbol
NDST3provided by HGNC
Official Full Name
N-deacetylase and N-sulfotransferase 3provided by HGNC
Primary source
HGNC:HGNC:7682
See related
Ensembl:ENSG00000164100 MIM:603950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSST3
Summary
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NDST3 in Genome Data Viewer
Location:
4q26
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (118033322..118258945)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (118954477..119179789)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1378 Neighboring gene NT5C3A pseudogene 1 Neighboring gene uncharacterized LOC102723914 Neighboring gene long intergenic non-protein coding RNA 2264 Neighboring gene uncharacterized LOC107986307 Neighboring gene uncharacterized LOC105377392 Neighboring gene FKBP prolyl isomerase 4 pseudogene 1 Neighboring gene small nucleolar RNA, H/ACA box 24 Neighboring gene serine protease 12 Neighboring gene small nucleolar RNA host gene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC130028, MGC130029

General protein information

Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
Names
GlcNAc N-deacetylase/ N-sulfotransferase 3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
N-deacetylase/N-sulfotransferase 3
N-heparan sulfate sulfotransferase 3
glucosaminyl N-deacetylase/N-sulfotransferase 3
NP_004775.1
XP_006714479.1
XP_011530717.1
XP_011530718.1
XP_016864328.1
XP_016864329.1
XP_016864330.1
XP_016864331.1
XP_016864332.1
XP_016864333.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004784.3NP_004775.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

    See identical proteins and their annotated locations for NP_004775.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AF074924, BC034037, BE348441
    Consensus CDS
    CCDS3708.1
    UniProtKB/Swiss-Prot
    O95803
    Related
    ENSP00000296499.5, ENST00000296499.6
    Conserved Domains (2) summary
    pfam00685
    Location:595846
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:20506
    HSNSD; heparan sulfate-N-deacetylase

RNA

  1. NR_146513.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC096762, AC108201, AC110999, BC034037
  2. NR_146514.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC096762, AC108201, AC110999, BC034037

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    118033322..118258945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714416.3XP_006714479.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X2

    See identical proteins and their annotated locations for XP_006714479.1

    UniProtKB/Swiss-Prot
    O95803
    Conserved Domains (2) summary
    pfam00685
    Location:595846
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:20506
    HSNSD; heparan sulfate-N-deacetylase
  2. XM_017008840.2XP_016864329.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X1

  3. XM_017008839.2XP_016864328.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X1

  4. XM_011532415.3XP_011530717.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X3

    Conserved Domains (1) summary
    pfam12062
    Location:20506
    HSNSD; heparan sulfate-N-deacetylase
  5. XM_011532416.3XP_011530718.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X5

    Conserved Domains (1) summary
    pfam12062
    Location:20506
    HSNSD; heparan sulfate-N-deacetylase
  6. XM_017008842.1XP_016864331.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X6

  7. XM_017008844.1XP_016864333.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X4

  8. XM_017008841.1XP_016864330.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X4

  9. XM_017008843.1XP_016864332.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X7

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