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ZNF670 zinc finger protein 670 [ Homo sapiens (human) ]

Gene ID: 93474, updated on 8-Dec-2022

Summary

Official Symbol
ZNF670provided by HGNC
Official Full Name
zinc finger protein 670provided by HGNC
Primary source
HGNC:HGNC:28167
See related
Ensembl:ENSG00000277462 AllianceGenome:HGNC:28167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 1.7), endometrium (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF670 in Genome Data Viewer
Location:
1q44
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (247034637..247078811, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (246466233..246510418, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247197939..247242113, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ZNF670-ZNF695 readthrough (NMD candidate) Neighboring gene zinc finger protein 695 Neighboring gene Sharpr-MPRA regulatory region 11618 Neighboring gene zinc finger protein 519 pseudogene Neighboring gene DNA primase subunit 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 11854 Neighboring gene zinc finger protein 669 Neighboring gene uncharacterized LOC400812

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12606, MGC12466

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204220.2NP_001191149.1  zinc finger protein 670 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AL512637, DA757117, DB291578, DB367437
    Conserved Domains (5) summary
    smart00349
    Location:446
    KRAB; krueppel associated box
    COG5048
    Location:222383
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:198218
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:238263
    zf-H2C2_2; Zinc-finger double domain
  2. NM_033213.5NP_149990.1  zinc finger protein 670 isoform 1

    See identical proteins and their annotated locations for NP_149990.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL512637, BC005360, DA757117, DB367437
    Consensus CDS
    CCDS31087.1
    UniProtKB/Swiss-Prot
    Q9BS34
    Related
    ENSP00000355459.2, ENST00000366503.3
    Conserved Domains (3) summary
    COG5048
    Location:223384
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:344
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    247034637..247078811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    246466233..246510418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)