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TAOK2 TAO kinase 2 [ Homo sapiens (human) ]

Gene ID: 9344, updated on 11-Sep-2019

Summary

Official Symbol
TAOK2provided by HGNC
Official Full Name
TAO kinase 2provided by HGNC
Primary source
HGNC:HGNC:16835
See related
Ensembl:ENSG00000149930 MIM:613199
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSK; PSK1; TAO1; TAO2; MAP3K17; PSK1-BETA
Summary
This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in fat (RPKM 12.5), testis (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See TAOK2 in Genome Data Viewer
Location:
16p11.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (29973868..29992261)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29985188..30003583)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984836 Neighboring gene transmembrane protein 219 Neighboring gene HIRA interacting protein 3 Neighboring gene INO80 complex subunit E Neighboring gene double C2 domain alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0881

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
neuropilin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
activation of MAPKK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPKK activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
basal dendrite arborization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
basal dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell migration NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
mitotic G2 DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein targeting to membrane NAS
Non-traceable Author Statement
more info
PubMed 
regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
axon ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
dendritic growth cone ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase TAO2
Names
PSK-1
hKFC-C
kinase from chicken homolog C
prostate derived STE20-like kinase PSK
prostate-derived STE20-like kinase 1
prostate-derived sterile 20-like kinase 1
thousand and one amino acid protein kinase 2
NP_001238972.1
NP_004774.1
NP_057235.2
XP_011544284.1
XP_011544285.1
XP_011544286.1
XP_011544287.1
XP_011544288.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030462.1 RefSeqGene

    Range
    5002..23395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252043.2NP_001238972.1  serine/threonine-protein kinase TAO2 isoform 3

    See identical proteins and their annotated locations for NP_001238972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is alternatively spliced at the 3' end compared to variant 1. However, it maintains the reading frame, and encodes a shorter isoform (3) missing a protein segment compared to isoform 1.
    Source sequence(s)
    BC144344, BC151221, BP233788
    Consensus CDS
    CCDS58448.1
    UniProtKB/Swiss-Prot
    Q9UL54
    Related
    ENSP00000440336.1, ENST00000543033.5
    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  2. NM_004783.4NP_004774.1  serine/threonine-protein kinase TAO2 isoform 2

    See identical proteins and their annotated locations for NP_004774.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains alternate exons at the 3' end compared to variant 1. This results in a shorter isoform (2, also known as PSK1-beta) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF263313, AI805725, BC152413, BP233788, CN286840
    Consensus CDS
    CCDS10662.1
    UniProtKB/Swiss-Prot
    Q9UL54
    Related
    ENSP00000279394.3, ENST00000279394.7
    Conserved Domains (2) summary
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
    cl25732
    Location:478913
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_016151.4NP_057235.2  serine/threonine-protein kinase TAO2 isoform 1

    See identical proteins and their annotated locations for NP_057235.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as PSK1-alpha).
    Source sequence(s)
    BC136653, BC151221, BP233788
    Consensus CDS
    CCDS10663.1
    UniProtKB/Swiss-Prot
    Q9UL54
    Related
    ENSP00000310094.4, ENST00000308893.9
    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    29973868..29992261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545984.2XP_011544286.1  serine/threonine-protein kinase TAO2 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  2. XM_011545985.2XP_011544287.1  serine/threonine-protein kinase TAO2 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  3. XM_011545986.3XP_011544288.1  serine/threonine-protein kinase TAO2 isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  4. XM_011545982.2XP_011544284.1  serine/threonine-protein kinase TAO2 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  5. XM_011545983.3XP_011544285.1  serine/threonine-protein kinase TAO2 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

RNA

  1. XR_001752034.2 RNA Sequence

  2. XR_001752036.2 RNA Sequence

  3. XR_001752035.2 RNA Sequence

  4. XR_950873.2 RNA Sequence

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