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TAOK2 TAO kinase 2 [ Homo sapiens (human) ]

Gene ID: 9344, updated on 8-Jul-2021

Summary

Official Symbol
TAOK2provided by HGNC
Official Full Name
TAO kinase 2provided by HGNC
Primary source
HGNC:HGNC:16835
See related
Ensembl:ENSG00000149930 MIM:613199
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSK; PSK1; TAO1; TAO2; MAP3K17; PSK1-BETA
Summary
This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in fat (RPKM 12.5), testis (RPKM 11.6) and 25 other tissues See more
Orthologs
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Genomic context

See TAOK2 in Genome Data Viewer
Location:
16p11.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (29973868..29992261)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29985189..30003582)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene KCTD13 divergent transcript Neighboring gene transmembrane protein 219 Neighboring gene HIRA interacting protein 3 Neighboring gene INO80 complex subunit E Neighboring gene double C2 domain alpha Neighboring gene chromosome 16 open reading frame 92

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0881

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables neuropilin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in basal dendrite arborization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in basal dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein targeting to membrane NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in dendritic growth cone ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase TAO2
Names
PSK-1
hKFC-C
kinase from chicken homolog C
prostate derived STE20-like kinase PSK
prostate-derived STE20-like kinase 1
prostate-derived sterile 20-like kinase 1
thousand and one amino acid protein kinase 2
NP_001238972.1
NP_004774.1
NP_057235.2
XP_011544284.1
XP_011544285.1
XP_011544286.1
XP_011544287.1
XP_011544288.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030462.1 RefSeqGene

    Range
    5002..23395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252043.2NP_001238972.1  serine/threonine-protein kinase TAO2 isoform 3

    See identical proteins and their annotated locations for NP_001238972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is alternatively spliced at the 3' end compared to variant 1. However, it maintains the reading frame, and encodes a shorter isoform (3) missing a protein segment compared to isoform 1.
    Source sequence(s)
    BC144344, BC151221, BP233788
    Consensus CDS
    CCDS58448.1
    UniProtKB/Swiss-Prot
    Q9UL54
    Related
    ENSP00000440336.1, ENST00000543033.5
    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  2. NM_004783.4NP_004774.1  serine/threonine-protein kinase TAO2 isoform 2

    See identical proteins and their annotated locations for NP_004774.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains alternate exons at the 3' end compared to variant 1. This results in a shorter isoform (2, also known as PSK1-beta) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF263313, AI805725, BC152413, BP233788, CN286840
    Consensus CDS
    CCDS10662.1
    UniProtKB/Swiss-Prot
    Q9UL54
    Related
    ENSP00000279394.3, ENST00000279394.7
    Conserved Domains (2) summary
    COG0419
    Location:478913
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  3. NM_016151.4NP_057235.2  serine/threonine-protein kinase TAO2 isoform 1

    See identical proteins and their annotated locations for NP_057235.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as PSK1-alpha).
    Source sequence(s)
    BC136653, BC151221, BP233788
    Consensus CDS
    CCDS10663.1
    UniProtKB/Swiss-Prot
    Q9UL54
    Related
    ENSP00000310094.4, ENST00000308893.9
    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    29973868..29992261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545984.2XP_011544286.1  serine/threonine-protein kinase TAO2 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  2. XM_011545985.2XP_011544287.1  serine/threonine-protein kinase TAO2 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  3. XM_011545986.3XP_011544288.1  serine/threonine-protein kinase TAO2 isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  4. XM_011545982.2XP_011544284.1  serine/threonine-protein kinase TAO2 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
  5. XM_011545983.3XP_011544285.1  serine/threonine-protein kinase TAO2 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:28281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06634
    Location:12319
    STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

RNA

  1. XR_001752034.2 RNA Sequence

  2. XR_001752036.2 RNA Sequence

  3. XR_001752035.2 RNA Sequence

  4. XR_950873.2 RNA Sequence

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