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SYCE1 synaptonemal complex central element protein 1 [ Homo sapiens (human) ]

Gene ID: 93426, updated on 23-Nov-2021

Summary

Official Symbol
SYCE1provided by HGNC
Official Full Name
synaptonemal complex central element protein 1provided by HGNC
Primary source
HGNC:HGNC:28852
See related
Ensembl:ENSG00000171772 MIM:611486
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT76; POF12; SPGF15; C10orf94
Summary
This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Expression
Biased expression in testis (RPKM 31.6), placenta (RPKM 4.3) and 1 other tissue See more
Orthologs
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Genomic context

See SYCE1 in Genome Data Viewer
Location:
10q26.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (133553899..133568291, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135367403..135381795, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984284 Neighboring gene CYP2E1 5' regulatory region Neighboring gene cytochrome P450 family 2 subfamily E member 1 Neighboring gene shadow of prion protein pseudogene 1 Neighboring gene olfactory receptor family 6 subfamily L member 1 pseudogene Neighboring gene FSHD region gene 2 family member B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CYP2E1

Homology

Clone Names

  • FLJ99976

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptonemal complex assembly IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
located_in central element ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
synaptonemal complex central element protein 1
Names
cancer/testis antigen 76
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052008.1 RefSeqGene

    Range
    7642..19376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001143763.2NP_001137235.1  synaptonemal complex central element protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001137235.1

    Status: REVIEWED

    Source sequence(s)
    AK314978, AL161645, DB053356, DB336153
    Consensus CDS
    CCDS44500.1
    UniProtKB/Swiss-Prot
    Q8N0S2
    UniProtKB/TrEMBL
    A0A0B4J1R9
    Related
    ENSP00000303978.5, ENST00000303903.10
    Conserved Domains (1) summary
    pfam15233
    Location:52198
    SYCE1; Synaptonemal complex central element protein 1
  2. NM_001143764.3NP_001137236.1  synaptonemal complex central element protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001137236.1

    Status: REVIEWED

    Source sequence(s)
    AK314978, AL161645, BC034821, DB053356
    Related
    ENSP00000341282.5, ENST00000343131.7
    Conserved Domains (1) summary
    pfam15233
    Location:52198
    SYCE1; Synaptonemal complex central element protein 1
  3. NM_130784.4NP_570140.1  synaptonemal complex central element protein 1 isoform 1

    See identical proteins and their annotated locations for NP_570140.1

    Status: REVIEWED

    Source sequence(s)
    AL161645, AY027807, DB336153
    Consensus CDS
    CCDS7687.1
    UniProtKB/Swiss-Prot
    Q8N0S2
    Related
    ENSP00000357503.3, ENST00000368517.7
    Conserved Domains (1) summary
    pfam15233
    Location:16162
    SYCE1; Synaptonemal complex central element protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    133553899..133568291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_201564.1: Suppressed sequence

    Description
    NM_201564.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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