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MYL10 myosin light chain 10 [ Homo sapiens (human) ]

Gene ID: 93408, updated on 13-May-2022

Summary

Official Symbol
MYL10provided by HGNC
Official Full Name
myosin light chain 10provided by HGNC
Primary source
HGNC:HGNC:29825
See related
Ensembl:ENSG00000106436 MIM:617177; AllianceGenome:HGNC:29825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLRLC; MYLC2PL
Summary
Predicted to enable calcium ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See MYL10 in Genome Data Viewer
Location:
7q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (101613330..101629296, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102933202..102949180, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (101256610..101272576, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986832 Neighboring gene long intergenic non-protein coding RNA 1007 Neighboring gene cut like homeobox 1 Neighboring gene Sharpr-MPRA regulatory region 716 Neighboring gene Sharpr-MPRA regulatory region 4286

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
myosin regulatory light chain 10
Names
myosin light chain 2, lymphocyte-specific
myosin light chain 2, precursor lymphocyte-specific
myosin, light chain 10, regulatory
precursor lymphocyte-specific regulatory light chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138403.5NP_612412.2  myosin regulatory light chain 10

    See identical proteins and their annotated locations for NP_612412.2

    Status: VALIDATED

    Source sequence(s)
    AC004953, BC002778
    Consensus CDS
    CCDS34713.1
    UniProtKB/Swiss-Prot
    Q9BUA6
    Related
    ENSP00000223167.4, ENST00000223167.5
    Conserved Domains (2) summary
    COG5126
    Location:40223
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15897
    Location:89118
    EFh_PEF; EF-hand motif [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    101613330..101629296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012793.2XP_016868282.1  myosin regulatory light chain 10 isoform X1

    Related
    ENSP00000493793.2, ENST00000642629.2
    Conserved Domains (1) summary
    COG5126
    Location:1144
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    102933202..102949180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)