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MMGT1 membrane magnesium transporter 1 [ Homo sapiens (human) ]

Gene ID: 93380, updated on 4-Jul-2021

Summary

Official Symbol
MMGT1provided by HGNC
Official Full Name
membrane magnesium transporter 1provided by HGNC
Primary source
HGNC:HGNC:28100
See related
Ensembl:ENSG00000169446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMC5; TMEM32
Expression
Ubiquitous expression in thyroid (RPKM 15.3), bone marrow (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

See MMGT1 in Genome Data Viewer
Location:
Xq26.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (135960588..135973988, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135042747..135056147, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene sarcoma antigen 1 Neighboring gene cancer/testis antigen family 45 member A11, pseudogene Neighboring gene solute carrier family 9 member A6 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 67

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with membrane magnesium transporter 1 (MMGT1; TMEM32) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables inorganic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to membrane insertase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of EMC complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ER membrane protein complex subunit 5
Names
transmembrane protein 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330000.2NP_001316929.1  ER membrane protein complex subunit 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL953870, BC033588, DC401453
    Consensus CDS
    CCDS14653.1
    UniProtKB/Swiss-Prot
    Q8N4V1
    Related
    ENSP00000505226.1, ENST00000679621.1
    Conserved Domains (1) summary
    pfam10270
    Location:2961
    MMgT; Membrane magnesium transporter
  2. NM_173470.3NP_775741.1  ER membrane protein complex subunit 5 precursor

    See identical proteins and their annotated locations for NP_775741.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL732579, AL953870
    Consensus CDS
    CCDS14653.1
    UniProtKB/Swiss-Prot
    Q8N4V1
    Related
    ENSP00000306220.2, ENST00000305963.3
    Conserved Domains (1) summary
    pfam10270
    Location:2961
    MMgT; Membrane magnesium transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    135960588..135973988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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