U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OPALIN oligodendrocytic myelin paranodal and inner loop protein [ Homo sapiens (human) ]

Gene ID: 93377, updated on 9-Dec-2024

Summary

Official Symbol
OPALINprovided by HGNC
Official Full Name
oligodendrocytic myelin paranodal and inner loop proteinprovided by HGNC
Primary source
HGNC:HGNC:20707
See related
Ensembl:ENSG00000197430 MIM:617200; AllianceGenome:HGNC:20707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMP10; HTMP10; TMEM10
Summary
Predicted to be involved in regulation of oligodendrocyte differentiation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward brain (RPKM 29.7) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See OPALIN in Genome Data Viewer
Location:
10q24.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (96343221..96359002, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (97222521..97238300, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (98102978..98118759, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902487 Neighboring gene B cell linker Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:97995995-97996494 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:98026632-98027831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3826 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:98068473-98069311 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:98069312-98070152 Neighboring gene NANOG hESC enhancer GRCh37_chr10:98084017-98084578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2653 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:98104629-98105395 Neighboring gene DNA nucleotidylexotransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:98138703-98139212 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:98156871-98157399 Neighboring gene tolloid like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:98201903-98202541 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:98210491-98210992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:98246593-98247092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:98262485-98262985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:98265857-98266640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:98271755-98272274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3827 Neighboring gene transmembrane 9 superfamily member 3 Neighboring gene nucleophosmin 1 pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in cell-cell contact zone IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
opalin
Names
transmembrane protein 10
transmembrane protein TMP10

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040102.3NP_001035191.1  opalin isoform b

    See identical proteins and their annotated locations for NP_001035191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AF367761, AL834229, BC033737, DA314221, DA399715
    Consensus CDS
    CCDS41556.1
    UniProtKB/Swiss-Prot
    Q96PE5
    Related
    ENSP00000377449.1, ENST00000393871.5
  2. NM_001040103.3NP_001035192.1  opalin isoform c

    See identical proteins and their annotated locations for NP_001035192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon and uses an alternate start codon compared to variant 1. It encodes isoform c which is shorter and has a distinct N-terminus compared to isoform a. Variants 3, 6, 7 and 8 encode the same isoform (c).
    Source sequence(s)
    AF367761, AK316090, AL834229, BC033737, DA314221
    Consensus CDS
    CCDS44466.1
    UniProtKB/Swiss-Prot
    Q96PE5
    Related
    ENSP00000484599.1, ENST00000611913.4
  3. NM_001284320.2NP_001271249.1  opalin isoform d

    See identical proteins and their annotated locations for NP_001271249.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform d), compared to isoform a.
    Source sequence(s)
    AK296562, AL834229, BC033737, DA314221
    Consensus CDS
    CCDS60602.1
    UniProtKB/Swiss-Prot
    Q96PE5
    Related
    ENSP00000398025.2, ENST00000419479.5
  4. NM_001284321.2NP_001271250.1  opalin isoform e

    See identical proteins and their annotated locations for NP_001271250.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform e), compared to isoform a.
    Source sequence(s)
    AK296562, AL834229, BC033737, DA291461
    Consensus CDS
    CCDS73173.1
    UniProtKB/TrEMBL
    A0A0A0MS47
    Related
    ENSP00000377448.3, ENST00000393870.3
  5. NM_001284322.2NP_001271251.1  opalin isoform c

    See identical proteins and their annotated locations for NP_001271251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate exon and uses an alternate start codon compared to variant 1. It encodes isoform c which is shorter and has a distinct N-terminus compared to isoform a. Variants 3, 6, 7 and 8 encode the same isoform (c).
    Source sequence(s)
    AK296562, AL834229, BC033737, HY120079
    Consensus CDS
    CCDS44466.1
    UniProtKB/Swiss-Prot
    Q96PE5
  6. NM_001284323.2NP_001271252.1  opalin isoform c

    See identical proteins and their annotated locations for NP_001271252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains two alternate exons and uses an alternate start codon compared to variant 1. It encodes isoform c which is shorter and has a distinct N-terminus compared to isoform a. Variants 3, 6, 7 and 8 encode the same isoform (c).
    Source sequence(s)
    AK296562, AL834229, BC033737, DA232955
    Consensus CDS
    CCDS44466.1
    UniProtKB/Swiss-Prot
    Q96PE5
  7. NM_001284324.2NP_001271253.1  opalin isoform c

    See identical proteins and their annotated locations for NP_001271253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains two alternate exons and uses an alternate start codon compared to variant 1. It encodes isoform c which is shorter and has a distinct N-terminus compared to isoform a. Variants 3, 6, 7 and 8 encode the same isoform (c).
    Source sequence(s)
    AK296462, AK296562, AL834229, BC033737
    Consensus CDS
    CCDS44466.1
    UniProtKB/Swiss-Prot
    Q96PE5
  8. NM_001284326.2NP_001271255.1  opalin isoform f

    See identical proteins and their annotated locations for NP_001271255.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform f which has a shorter N-terminus compared to isoform a. Variants 9 and 10 encode the same isoform (f).
    Source sequence(s)
    AK296562, AL834229, BC033737, BP349325, DA232955
    Consensus CDS
    CCDS73172.1
    UniProtKB/TrEMBL
    A0A0A0MTN4
    Related
    ENSP00000445125.2, ENST00000536387.5
  9. NM_001284327.2NP_001271256.1  opalin isoform f

    See identical proteins and their annotated locations for NP_001271256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) uses an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform f which has a shorter N-terminus compared to isoform a. Variants 9 and 10 encode the same isoform (f).
    Source sequence(s)
    AK296562, AL834229, BC033737, CK023662
    Consensus CDS
    CCDS73172.1
    UniProtKB/TrEMBL
    A0A0A0MTN4
  10. NM_033207.5NP_149984.1  opalin isoform a

    See identical proteins and their annotated locations for NP_149984.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF367761, AL834229, BC033737, DA314221
    Consensus CDS
    CCDS7448.1
    UniProtKB/Swiss-Prot
    A8MX69, A8MYG4, B4DK96, B4DKH0, Q5W102, Q96PE5
    Related
    ENSP00000360214.3, ENST00000371172.8

RNA

  1. NR_104296.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) uses alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK296562, AL136181, AL834229, BC033737, DA351452, HY120079
  2. NR_104297.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) uses alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK296562, AL834229, BC033737, DA314221, DA399407

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    96343221..96359002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    97222521..97238300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)