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SP140L SP140 nuclear body protein like [ Homo sapiens (human) ]

Gene ID: 93349, updated on 23-Nov-2021

Summary

Official Symbol
SP140Lprovided by HGNC
Official Full Name
SP140 nuclear body protein likeprovided by HGNC
Primary source
HGNC:HGNC:25105
See related
Ensembl:ENSG00000185404 MIM:617747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in lymph node (RPKM 8.7), spleen (RPKM 8.3) and 24 other tissues See more
Orthologs
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Genomic context

See SP140L in Genome Data Viewer
Location:
2q37.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (230327152..230407506)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231191908..231268447)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985997 Neighboring gene SP110 nuclear body protein Neighboring gene SP140 nuclear body protein Neighboring gene uncharacterized LOC105373925 Neighboring gene uncharacterized LOC101928816 Neighboring gene SP100 nuclear antigen Neighboring gene RNA, 7SL, cytoplasmic 834, pseudogene Neighboring gene high mobility group box 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of behavioral disinhibition.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC132667

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear body protein SP140-like protein
Names
SP140L-1 protein
SP140L-2 protein
SP140L-3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308162.3NP_001295091.1  nuclear body protein SP140-like protein isoform 2

    See identical proteins and their annotated locations for NP_001295091.1

    Status: VALIDATED

    Source sequence(s)
    AC009949, AK023116, BX281497, DW428200, KF419365
    Consensus CDS
    CCDS77536.1
    UniProtKB/TrEMBL
    U5Y3L1
    Related
    ENSP00000243810.7, ENST00000243810.10
    Conserved Domains (4) summary
    cd05501
    Location:445548
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:380421
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:273348
    SAND; SAND domain
    pfam03172
    Location:27121
    Sp100; Sp100 domain
  2. NM_001308163.3NP_001295092.1  nuclear body protein SP140-like protein isoform 3

    See identical proteins and their annotated locations for NP_001295092.1

    Status: VALIDATED

    Source sequence(s)
    AC009949, AK023116, BX281497, DW428200, KF419366
    Consensus CDS
    CCDS77537.1
    UniProtKB/TrEMBL
    H7BYP4
    Related
    ENSP00000379811.5, ENST00000396563.8
    Conserved Domains (4) summary
    cd05501
    Location:410513
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:345386
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:261313
    SAND; SAND domain
    pfam03172
    Location:27121
    Sp100; Sp100 domain
  3. NM_001352892.2NP_001339821.1  nuclear body protein SP140-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC009949
    Conserved Domains (4) summary
    cd05501
    Location:461564
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:405439
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:298373
    SAND; SAND domain
    pfam03172
    Location:49147
    HSR; HSR domain
  4. NM_001352893.2NP_001339822.1  nuclear body protein SP140-like protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC009949
    Conserved Domains (4) summary
    cd05501
    Location:435538
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:370411
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:286338
    SAND; SAND domain
    pfam03172
    Location:49147
    HSR; HSR domain
  5. NM_001352894.2NP_001339823.1  nuclear body protein SP140-like protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC009949, KF419367
    Conserved Domains (4) summary
    cd05501
    Location:401504
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:345379
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:261313
    SAND; SAND domain
    pfam03172
    Location:24122
    HSR; HSR domain
  6. NM_138402.6NP_612411.4  nuclear body protein SP140-like protein isoform 1

    See identical proteins and their annotated locations for NP_612411.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009949, AK023116, AU130836, BQ232706, BQ690359, CR987282, DB240458
    Consensus CDS
    CCDS46538.1
    UniProtKB/Swiss-Prot
    Q9H930
    Related
    ENSP00000397911.2, ENST00000415673.7
    Conserved Domains (4) summary
    cd05501
    Location:470573
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:405446
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:298373
    SAND; SAND domain
    pfam03172
    Location:52146
    Sp100; Sp100 domain

RNA

  1. NR_148198.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009949

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    230327152..230407506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005297.1XP_016860786.1  nuclear body protein SP140-like protein isoform X4

  2. XM_017005299.1XP_016860788.1  nuclear body protein SP140-like protein isoform X6

  3. XM_017005294.1XP_016860783.1  nuclear body protein SP140-like protein isoform X1

  4. XM_017005295.1XP_016860784.1  nuclear body protein SP140-like protein isoform X2

  5. XM_017005298.1XP_016860787.1  nuclear body protein SP140-like protein isoform X5

  6. XM_017005296.1XP_016860785.1  nuclear body protein SP140-like protein isoform X3

  7. XM_006712856.2XP_006712919.1  nuclear body protein SP140-like protein isoform X7

    Conserved Domains (4) summary
    cd05501
    Location:426529
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:370404
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:286338
    SAND; SAND domain
    pfam03172
    Location:52146
    Sp100; Sp100 domain
  8. XM_011512190.3XP_011510492.1  nuclear body protein SP140-like protein isoform X8

    Related
    ENSP00000395195.1, ENST00000444636.5
    Conserved Domains (3) summary
    cd15626
    Location:422455
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:315390
    SAND; SAND domain
    pfam03172
    Location:52146
    Sp100; Sp100 domain
  9. XM_011512191.1XP_011510493.1  nuclear body protein SP140-like protein isoform X10

    Conserved Domains (2) summary
    pfam03172
    Location:52146
    Sp100; Sp100 domain
    cl02536
    Location:315344
    SAND; SAND domain
  10. XM_017005301.2XP_016860790.1  nuclear body protein SP140-like protein isoform X9

RNA

  1. XR_001739075.1 RNA Sequence

  2. XR_002959365.1 RNA Sequence

  3. XR_923066.1 RNA Sequence

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