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GTF3C3 general transcription factor IIIC subunit 3 [ Homo sapiens (human) ]

Gene ID: 9330, updated on 15-Apr-2019

Summary

Official Symbol
GTF3C3provided by HGNC
Official Full Name
general transcription factor IIIC subunit 3provided by HGNC
Primary source
HGNC:HGNC:4666
See related
Ensembl:ENSG00000119041 MIM:604888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIIC102; TFIIICgamma; TFiiiC2-102
Summary
The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in testis (RPKM 7.9), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See GTF3C3 in Genome Data Viewer
Location:
2q33.1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (196763032..196799768, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (197627756..197664492, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373823 Neighboring gene coiled-coil domain containing 150 Neighboring gene uncharacterized LOC100130452 Neighboring gene chromosome 2 open reading frame 66 Neighboring gene post-GPI attachment to proteins 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of general transcription factor IIIC, polypeptide 3 (GTF3C3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IC
Inferred by Curator
more info
PubMed 
contributes_to RNA polymerase III general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase III transcription regulator recruiting activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
general transcription factor 3C polypeptide 3
Names
TF3C-gamma
TFIIIC 102 kDa subunit
general transcription factor IIIC, polypeptide 3, 102kDa
transcription factor IIIC subunit gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030373.1 RefSeqGene

    Range
    5001..41737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206774.1NP_001193703.1  general transcription factor 3C polypeptide 3 isoform 2

    See identical proteins and their annotated locations for NP_001193703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple exons from the 3' end and has an alternate 3' segment, compared to variant 1. The resulting isoform (2) has a much shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF465407, DB078021
    Consensus CDS
    CCDS56153.1
    UniProtKB/Swiss-Prot
    Q9Y5Q9
    Related
    ENSP00000386465.3, ENST00000409364.3
    Conserved Domains (2) summary
    sd00006
    Location:183211
    TPR; TPR repeat [structural motif]
    cl26002
    Location:145346
    TPR_11; TPR repeat
  2. NM_012086.5NP_036218.1  general transcription factor 3C polypeptide 3 isoform 1

    See identical proteins and their annotated locations for NP_036218.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC012486, AK314718
    Consensus CDS
    CCDS2316.1
    UniProtKB/Swiss-Prot
    Q9Y5Q9
    Related
    ENSP00000263956.3, ENST00000263956.8
    Conserved Domains (4) summary
    smart00028
    Location:812842
    TPR; Tetratricopeptide repeats
    sd00006
    Location:183211
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:216280
    TPR_11; TPR repeat
    pfam13432
    Location:425489
    TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    196763032..196799768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246965.4XP_005247022.1  general transcription factor 3C polypeptide 3 isoform X1

    Conserved Domains (3) summary
    smart00028
    Location:420450
    TPR; Tetratricopeptide repeats
    sd00006
    Location:3057
    TPR; TPR repeat [structural motif]
    pfam13432
    Location:3397
    TPR_16; Tetratricopeptide repeat
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