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GTF3C5 general transcription factor IIIC subunit 5 [ Homo sapiens (human) ]

Gene ID: 9328, updated on 23-Nov-2021

Summary

Official Symbol
GTF3C5provided by HGNC
Official Full Name
general transcription factor IIIC subunit 5provided by HGNC
Primary source
HGNC:HGNC:4668
See related
Ensembl:ENSG00000148308 MIM:604890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIIC63; TFiiiC2-63; TFIIICepsilon
Expression
Ubiquitous expression in ovary (RPKM 17.0), testis (RPKM 11.6) and 25 other tissues See more
Orthologs
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Genomic context

See GTF3C5 in Genome Data Viewer
Location:
9q34.13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (133030689..133058503)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135906384..135933890)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 Neighboring gene small nucleolar RNA, C/D box 141A Neighboring gene uncharacterized LOC105376306 Neighboring gene microRNA 6877 Neighboring gene carboxyl ester lipase Neighboring gene carboxyl ester lipase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20857

General protein information

Preferred Names
general transcription factor 3C polypeptide 5
Names
TF3C-epsilon
TFIIIC 63 kDa subunit
general transcription factor IIIC, polypeptide 5, 63kDa
transcription factor IIIC 63 kDa subunit
transcription factor IIIC subunit epsilon
transcription factor IIIC, 63 kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122823.2NP_001116295.1  general transcription factor 3C polypeptide 5 isoform 1

    See identical proteins and their annotated locations for NP_001116295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ420443, DB194811
    Consensus CDS
    CCDS48050.1
    UniProtKB/Swiss-Prot
    Q9Y5Q8
    Related
    ENSP00000361180.5, ENST00000372108.9
    Conserved Domains (1) summary
    pfam09734
    Location:24322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
  2. NM_001286709.2NP_001273638.1  general transcription factor 3C polypeptide 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' region, which results in translation initiation from an alternate start codon, and it lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL162417, BC017337, BQ673969, DB194811
    Consensus CDS
    CCDS75927.1
    UniProtKB/Swiss-Prot
    Q9Y5Q8
    UniProtKB/TrEMBL
    H7BY84
    Related
    ENSP00000361171.7, ENST00000372099.10
    Conserved Domains (1) summary
    pfam09734
    Location:25148
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
  3. NM_012087.4NP_036219.2  general transcription factor 3C polypeptide 5 isoform 2

    See identical proteins and their annotated locations for NP_036219.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, which results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AJ420443, AK055092
    Consensus CDS
    CCDS6958.1
    UniProtKB/Swiss-Prot
    Q9Y5Q8
    Related
    ENSP00000361169.5, ENST00000372097.10
    Conserved Domains (1) summary
    pfam09734
    Location:24322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    133030689..133058503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015315.1XP_016870804.1  general transcription factor 3C polypeptide 5 isoform X1

  2. XM_017015316.1XP_016870805.1  general transcription factor 3C polypeptide 5 isoform X2

RNA

  1. XR_002956827.1 RNA Sequence

  2. XR_002956826.1 RNA Sequence

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