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ZNHIT3 zinc finger HIT-type containing 3 [ Homo sapiens (human) ]

Gene ID: 9326, updated on 6-May-2021

Summary

Official Symbol
ZNHIT3provided by HGNC
Official Full Name
zinc finger HIT-type containing 3provided by HGNC
Primary source
HGNC:HGNC:12309
See related
Ensembl:ENSG00000273611 MIM:604500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hit1; PEHO; TRIP3
Expression
Ubiquitous expression in ovary (RPKM 10.5), testis (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNHIT3 in Genome Data Viewer
Location:
17q12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (36486681..36499312)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34842525..34855156)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 3J, pseudogene Neighboring gene uncharacterized LOC105371749 Neighboring gene RNA, 5S ribosomal pseudogene 439 Neighboring gene myosin XIX Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene gametogenetin binding protein 2 Neighboring gene ribosomal protein S2 pseudogene 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thyroid hormone receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
involved_in snoRNA localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of pre-snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger HIT domain-containing protein 3
Names
HNF-4a coactivator
TR-interacting protein 3
TRIP-3
thyroid hormone receptor interactor 3
thyroid receptor interacting protein 3
zinc finger, HIT domain containing 3
zinc finger, HIT type 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281432.2NP_001268361.1  zinc finger HIT domain-containing protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, which results in a frame-shift compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC233698, AK096494, AK308583, BI767446, HY045632
    Consensus CDS
    CCDS62156.1
    UniProtKB/Swiss-Prot
    Q15649
    Related
    ENSP00000479727.1, ENST00000620324.4
    Conserved Domains (1) summary
    pfam04438
    Location:736
    zf-HIT; HIT zinc finger
  2. NM_001281433.2NP_001268362.1  zinc finger HIT domain-containing protein 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate acceptor splice site at the penultimate coding exon, which results in a frame-shift compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF400652, BG032116, BQ009986, HY045632
    UniProtKB/Swiss-Prot
    Q15649
    Conserved Domains (1) summary
    pfam04438
    Location:736
    zf-HIT; HIT zinc finger
  3. NM_001281434.2NP_001268363.1  zinc finger HIT domain-containing protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive in-frame coding exons compared to variant 1. The resulting isoform (3) is shorter, missing an internal protein segment, compared to isoform 1.
    Source sequence(s)
    AF400652, BE260293, BQ009986, HY045632
    UniProtKB/Swiss-Prot
    Q15649
    Related
    ENSP00000481522.1, ENST00000616269.1
    Conserved Domains (1) summary
    pfam04438
    Location:736
    zf-HIT; HIT zinc finger
  4. NM_004773.4NP_004764.1  zinc finger HIT domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_004764.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF400652, BQ009986
    Consensus CDS
    CCDS11312.1
    UniProtKB/Swiss-Prot
    Q15649
    UniProtKB/TrEMBL
    A0A024R0X8
    Related
    ENSP00000484687.1, ENST00000617429.5
    Conserved Domains (1) summary
    pfam04438
    Location:736
    zf-HIT; HIT zinc finger

RNA

  1. NR_104009.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate acceptor splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF400652, BM457955, BQ009986, HY045632
    Related
    ENST00000620863.4
  2. NR_104010.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 5' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF400652, BC105608, BQ009986
    Related
    ENST00000619730.4
  3. NR_104011.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an exon in the 5' region and contains an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC233698, AK096494, AK308583, HY045632
    Related
    ENST00000612728.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    36486681..36499312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    721585..734216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033577.1: Suppressed sequence

    Description
    NM_001033577.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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