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TRIP4 thyroid hormone receptor interactor 4 [ Homo sapiens (human) ]

Gene ID: 9325, updated on 17-Sep-2024

Summary

Official Symbol
TRIP4provided by HGNC
Official Full Name
thyroid hormone receptor interactor 4provided by HGNC
Primary source
HGNC:HGNC:12310
See related
Ensembl:ENSG00000103671 MIM:604501; AllianceGenome:HGNC:12310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASC1; ASC-1; MDCDC; SMABF1; ZC2HC5; HsT17391
Summary
This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in thyroid (RPKM 15.4), kidney (RPKM 11.6) and 25 other tissues See more
Orthologs
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Genomic context

See TRIP4 in Genome Data Viewer
Location:
15q22.31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (64387836..64455303)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62197257..62264725)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64680035..64747502)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene casein kinase 1 gamma 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6533 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64652953-64653179 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64673301-64673811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64679750-64680250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64680251-64680751 Neighboring gene PCNA clamp associated factor Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722213-64722724 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722725-64723236 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:64736443-64737642 Neighboring gene uncharacterized LOC105370861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9569 Neighboring gene zinc finger protein 609 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64803884-64804071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64820886-64821752 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64831500-64832000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64832001-64832501 Neighboring gene uncharacterized LOC101930091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9571 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 61 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64849587-64850088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64850089-64850588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64855291-64855860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64855861-64856430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9573 Neighboring gene ribosomal protein S26 pseudogene 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RQC-trigger complex IEA
Inferred from Electronic Annotation
more info
 
part_of activating signal cointegrator 1 complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
activating signal cointegrator 1
Names
TR-interacting protein 4
TRIP-4
thyroid receptor-interacting protein 4
zinc finger, C2HC5-type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046848.1 RefSeqGene

    Range
    5033..72500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321924.2NP_001308853.1  activating signal cointegrator 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal exon, which results in translation initiation at an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK314319, BC012448, DA712387
    UniProtKB/Swiss-Prot
    Q15650
    Conserved Domains (1) summary
    cd06554
    Location:204317
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
  2. NM_016213.5NP_057297.2  activating signal cointegrator 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK314319, BC012448, BG166305
    Consensus CDS
    CCDS10194.1
    UniProtKB/Swiss-Prot
    B2RAS0, Q15650, Q96ED7, Q9UKH0
    Related
    ENSP00000261884.3, ENST00000261884.8
    Conserved Domains (2) summary
    cd06554
    Location:434547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:168216
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

RNA

  1. NR_135855.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK314319, BC012448, BG166305

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    64387836..64455303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    62197257..62264725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)