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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_046848.1 RefSeqGene
- Range
-
5033..72500
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001321924.2 → NP_001308853.1 activating signal cointegrator 1 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal exon, which results in translation initiation at an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
- Source sequence(s)
-
AK314319, BC012448, DA712387
- UniProtKB/Swiss-Prot
-
Q15650
- Conserved Domains (1) summary
-
- cd06554
Location:204 → 317
- ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
-
NM_016213.5 → NP_057297.2 activating signal cointegrator 1 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longer isoform (1).
- Source sequence(s)
-
AK314319, BC012448, BG166305
- Consensus CDS
-
CCDS10194.1
- UniProtKB/Swiss-Prot
- B2RAS0, Q15650, Q96ED7, Q9UKH0
- Related
- ENSP00000261884.3, ENST00000261884.8
- Conserved Domains (2) summary
-
- cd06554
Location:434 → 547
- ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
- pfam06221
Location:168 → 216
- zf-C2HC5; Putative zinc finger motif, C2HC5-type
RNA
-
NR_135855.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AK314319, BC012448, BG166305
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000015.10 Reference GRCh38.p14 Primary Assembly
- Range
-
64387836..64455303
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060939.1 Alternate T2T-CHM13v2.0
- Range
-
62197257..62264725
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)