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TRIP10 thyroid hormone receptor interactor 10 [ Homo sapiens (human) ]

Gene ID: 9322, updated on 9-Dec-2018

Summary

Official Symbol
TRIP10provided by HGNC
Official Full Name
thyroid hormone receptor interactor 10provided by HGNC
Primary source
HGNC:HGNC:12304
See related
Ensembl:ENSG00000125733 MIM:604504
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STP; CIP4; HSTP; STOT; TRIP-10
Expression
Ubiquitous expression in esophagus (RPKM 54.6), fat (RPKM 34.4) and 22 other tissues See more
Orthologs

Genomic context

See TRIP10 in Genome Data Viewer
Location:
19p13.3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (6739682..6751526)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6739693..6751529)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene complement C3 Neighboring gene G protein-coupled receptor 108 Neighboring gene uncharacterized LOC107985302 Neighboring gene microRNA 6791 Neighboring gene SH2 domain containing 3A Neighboring gene vav guanine nucleotide exchange factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
  • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
    Insulin Pathway, organism-specific biosystem
    Insulin Pathway
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin-mediated glucose transport, organism-specific biosystem (from Pathway Interaction Database)
    Insulin-mediated glucose transport, organism-specific biosystem
    Insulin-mediated glucose transport
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity TAS
Traceable Author Statement
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
cell communication NAS
Non-traceable Author Statement
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
phagocytic cup IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cdc42-interacting protein 4
Names
TR-interacting protein 10
protein Felic
salt tolerant protein
salt tolerator
thyroid receptor-interacting protein 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288962.2NP_001275891.1  cdc42-interacting protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001275891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008760, AF502289, AY081141, CB997985, DB198268
    Consensus CDS
    CCDS74271.1
    UniProtKB/Swiss-Prot
    Q15642
    Related
    ENSP00000320117.7, ENST00000313244.13
    Conserved Domains (3) summary
    cd07653
    Location:5257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:395475
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:544598
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
  2. NM_001288963.1NP_001275892.1  cdc42-interacting protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001275892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, and uses an alternate splice site in the 3' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) lacks an internal segment and has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF380114, AK313296, AY081141, CB997985, DB198268
    Consensus CDS
    CCDS74272.1
    UniProtKB/Swiss-Prot
    Q15642
    UniProtKB/TrEMBL
    W4VSQ9
    Related
    ENSP00000469360.1, ENST00000596758.5
    Conserved Domains (2) summary
    cd07653
    Location:5257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:339419
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
  3. NM_004240.3NP_004231.1  cdc42-interacting protein 4 isoform 2

    See identical proteins and their annotated locations for NP_004231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK313296, AY081141, CB997985, DB198268
    Consensus CDS
    CCDS12172.1
    UniProtKB/Swiss-Prot
    Q15642
    Related
    ENSP00000320493.6, ENST00000313285.12
    Conserved Domains (3) summary
    cd07653
    Location:5257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:339419
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:488542
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

RNA

  1. NR_110231.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB072596, AK313296, AY081141, CB997985, DB198268
    Related
    ENST00000595305.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    6739682..6751526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722940.1XP_006723003.1  cdc42-interacting protein 4 isoform X1

    Conserved Domains (2) summary
    cd07653
    Location:5257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:395475
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
  2. XM_005259683.2XP_005259740.1  cdc42-interacting protein 4 isoform X2

    Related
    ENSP00000472580.1, ENST00000600677.5
    Conserved Domains (1) summary
    cd07653
    Location:5257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
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