Format

Send to:

Choose Destination

PIGM phosphatidylinositol glycan anchor biosynthesis class M [ Homo sapiens (human) ]

Gene ID: 93183, updated on 27-Jun-2020

Summary

Official Symbol
PIGMprovided by HGNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis class Mprovided by HGNC
Primary source
HGNC:HGNC:18858
See related
Ensembl:ENSG00000143315 MIM:610273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPI-MT-I
Summary
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See PIGM in Genome Data Viewer
Location:
1q23.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (160024953..160031990, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159997462..160001783, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SLAM family member 9 Neighboring gene long intergenic non-protein coding RNA 1133 Neighboring gene Fc receptor like 6 pseudogene 1 Neighboring gene ribosomal protein L27a pseudogene 2 Neighboring gene potassium inwardly rectifying channel subfamily J member 10 Neighboring gene potassium inwardly rectifying channel subfamily J member 9

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29896

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannosylation IEA
Inferred from Electronic Annotation
more info
 
preassembly of GPI anchor in ER membrane TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
glycosylphosphatidylinositol-mannosyltransferase I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GPI mannosyltransferase 1
Names
DPM:GlcN-(acyl-)PI mannosyltransferase
GPI mannosyltransferase I
PIG-M mannosyltransferase
dol-P-Man dependent GPI mannosyltransferase
phosphatidylinositol-glycan biosynthesis class M protein
NP_660150.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012238.1 RefSeqGene

    Range
    5001..9322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_145167.3NP_660150.1  GPI mannosyltransferase 1

    See identical proteins and their annotated locations for NP_660150.1

    Status: REVIEWED

    Source sequence(s)
    AL513302, BC019865, BX643162
    Consensus CDS
    CCDS1192.1
    UniProtKB/Swiss-Prot
    Q9H3S5
    Related
    ENSP00000357069.2, ENST00000368090.5
    Conserved Domains (1) summary
    pfam05007
    Location:140408
    Mannosyl_trans; Mannosyltransferase (PIG-M)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    160024953..160031990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center