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NREP neuronal regeneration related protein [ Homo sapiens (human) ]

Gene ID: 9315, updated on 24-Nov-2020

Summary

Official Symbol
NREPprovided by HGNC
Official Full Name
neuronal regeneration related proteinprovided by HGNC
Primary source
HGNC:HGNC:16834
See related
Ensembl:ENSG00000134986 MIM:607332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P311; PTZ17; SEZ17; D4S114; C5orf13; PRO1873
Expression
Ubiquitous expression in brain (RPKM 38.4), placenta (RPKM 35.3) and 24 other tissues See more
Orthologs

Genomic context

See NREP in Genome Data Viewer
Location:
5q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (111728802..111976932, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (111065000..111312628, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene STARD4 antisense RNA 1 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 13 Neighboring gene RN7SK pseudogene 57 Neighboring gene uncharacterized LOC105379122 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 14 Neighboring gene NREP antisense RNA 1 Neighboring gene EPB41L4A antisense RNA 1 Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene small nucleolar RNA, H/ACA box 13 Neighboring gene uncharacterized LOC101927023

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of neuronal regeneration related protein homolog (rat, NREP; P311; C5orf13) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon regeneration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neuronal regeneration-related protein
Names
neuronal protein 3.1
neuronal regeneration related protein homolog
protein p311

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142474.2NP_001135946.1  neuronal regeneration-related protein isoform b

    See identical proteins and their annotated locations for NP_001135946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes alternate exons in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform b, which is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC022108, AC025182, DA027062, DA694580
    Conserved Domains (1) summary
    pfam11092
    Location:37102
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  2. NM_001142475.2NP_001135947.1  neuronal regeneration-related protein isoform c

    See identical proteins and their annotated locations for NP_001135947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes alternate exons in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform c, which is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC022108, AC025182, DC365764
    Consensus CDS
    CCDS47255.1
    UniProtKB/Swiss-Prot
    Q16612
    Related
    ENSP00000378996.3, ENST00000395634.7
    Conserved Domains (1) summary
    pfam11092
    Location:47112
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  3. NM_001142476.1NP_001135948.1  neuronal regeneration-related protein isoform a

    See identical proteins and their annotated locations for NP_001135948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
    Source sequence(s)
    AC022108, DA490948, DA526263
    Consensus CDS
    CCDS4105.1
    UniProtKB/Swiss-Prot
    Q16612
    Related
    ENSP00000392559.2, ENST00000455559.6
    Conserved Domains (1) summary
    pfam11092
    Location:368
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  4. NM_001142477.1NP_001135949.1  neuronal regeneration-related protein isoform a

    See identical proteins and their annotated locations for NP_001135949.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
    Source sequence(s)
    AC022108, DA939543
    Consensus CDS
    CCDS4105.1
    UniProtKB/Swiss-Prot
    Q16612
    Related
    ENSP00000427476.1, ENST00000513100.5
    Conserved Domains (1) summary
    pfam11092
    Location:368
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  5. NM_001142478.2NP_001135950.1  neuronal regeneration-related protein isoform a

    See identical proteins and their annotated locations for NP_001135950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
    Source sequence(s)
    AC022108, AC114297, AL547663, BC011050
    Consensus CDS
    CCDS4105.1
    UniProtKB/Swiss-Prot
    Q16612
    Related
    ENSP00000368993.3, ENST00000379671.7
    Conserved Domains (1) summary
    pfam11092
    Location:368
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  6. NM_001142479.1NP_001135951.1  neuronal regeneration-related protein isoform a

    See identical proteins and their annotated locations for NP_001135951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
    Source sequence(s)
    AC022108, DA520221, DA704824
    Consensus CDS
    CCDS4105.1
    UniProtKB/Swiss-Prot
    Q16612
    Related
    ENSP00000399766.2, ENST00000419114.6
    Conserved Domains (1) summary
    pfam11092
    Location:368
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  7. NM_001142480.1NP_001135952.1  neuronal regeneration-related protein isoform a

    See identical proteins and their annotated locations for NP_001135952.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
    Source sequence(s)
    AC022108, DA704824, DA744980
    Consensus CDS
    CCDS4105.1
    UniProtKB/Swiss-Prot
    Q16612
    Conserved Domains (1) summary
    pfam11092
    Location:368
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  8. NM_001142481.1NP_001135953.1  neuronal regeneration-related protein isoform a

    See identical proteins and their annotated locations for NP_001135953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
    Source sequence(s)
    AC022108, DA752769
    Consensus CDS
    CCDS4105.1
    UniProtKB/Swiss-Prot
    Q16612
    Related
    ENSP00000422630.1, ENST00000509427.5
    Conserved Domains (1) summary
    pfam11092
    Location:368
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  9. NM_001142482.1NP_001135954.1  neuronal regeneration-related protein isoform a

    See identical proteins and their annotated locations for NP_001135954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
    Source sequence(s)
    AC022108, DA683910
    Consensus CDS
    CCDS4105.1
    UniProtKB/Swiss-Prot
    Q16612
    Related
    ENSP00000402965.2, ENST00000446294.6
    Conserved Domains (1) summary
    pfam11092
    Location:368
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  10. NM_001142483.1NP_001135955.1  neuronal regeneration-related protein isoform a

    See identical proteins and their annotated locations for NP_001135955.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
    Source sequence(s)
    AC022108, DA078027, DA534424
    Consensus CDS
    CCDS4105.1
    UniProtKB/Swiss-Prot
    Q16612
    Related
    ENSP00000408839.2, ENST00000447165.6
    Conserved Domains (1) summary
    pfam11092
    Location:368
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  11. NM_004772.4NP_004763.1  neuronal regeneration-related protein isoform a

    See identical proteins and their annotated locations for NP_004763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (a). Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
    Source sequence(s)
    BC072443, CN415439
    Consensus CDS
    CCDS4105.1
    UniProtKB/Swiss-Prot
    Q16612
    Related
    ENSP00000257435.7, ENST00000257435.12
    Conserved Domains (1) summary
    pfam11092
    Location:368
    Alveol-reg_P311; Neuronal protein 3.1 (p311)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    111728802..111976932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714733.2XP_006714796.1  neuronal regeneration-related protein isoform X2

    Conserved Domains (1) summary
    pfam11092
    Location:2287
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
  2. XM_006714732.1XP_006714795.1  neuronal regeneration-related protein isoform X1

    See identical proteins and their annotated locations for XP_006714795.1

    Conserved Domains (1) summary
    pfam11092
    Location:2893
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
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