Format

Send to:

Choose Destination

OLFM2 olfactomedin 2 [ Homo sapiens (human) ]

Gene ID: 93145, updated on 11-Jun-2021

Summary

Official Symbol
OLFM2provided by HGNC
Official Full Name
olfactomedin 2provided by HGNC
Primary source
HGNC:HGNC:17189
See related
Ensembl:ENSG00000105088 MIM:617492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOE2; OlfC; NOELIN2; NOELIN2_V1
Expression
Biased expression in brain (RPKM 38.1), skin (RPKM 32.4) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See OLFM2 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (9853718..9936515, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9964394..10047191, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PIN1 divergent transcript Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Neighboring gene collagen type V alpha 3 chain Neighboring gene retinol dehydrogenase 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
noelin-2
Names
neuronal olfactomedin related ER localized protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304347.2NP_001291276.1  noelin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008742, AC008752, BC011361, BE252295, BQ069013
    UniProtKB/Swiss-Prot
    O95897
    Related
    ENSP00000465809.2, ENST00000593091.2
    Conserved Domains (2) summary
    pfam02191
    Location:222466
    OLF; Olfactomedin-like domain
    pfam12308
    Location:49144
    Noelin-1; Neurogenesis glycoprotein
  2. NM_001304348.2NP_001291277.1  noelin-2 isoform 3

    See identical proteins and their annotated locations for NP_001291277.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC008742, AC008752, BC011361, BI907480, BX437233
    Consensus CDS
    CCDS77230.1
    UniProtKB/Swiss-Prot
    O95897
    UniProtKB/TrEMBL
    K7EIS8
    Related
    ENSP00000464877.1, ENST00000590841.5
    Conserved Domains (3) summary
    pfam02191
    Location:120364
    OLF; Olfactomedin-like domain
    pfam12308
    Location:142
    Noelin-1; Neurogenesis glycoprotein
    cl25732
    Location:23115
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_058164.4NP_477512.1  noelin-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_477512.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC008752, AL538120, BC011361
    Consensus CDS
    CCDS12221.1
    UniProtKB/Swiss-Prot
    O95897
    Related
    ENSP00000264833.3, ENST00000264833.9
    Conserved Domains (2) summary
    pfam02191
    Location:198442
    OLF; Olfactomedin-like domain
    pfam12308
    Location:25120
    Noelin-1; Neurogenesis glycoprotein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    9853718..9936515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center