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ORAI3 ORAI calcium release-activated calcium modulator 3 [ Homo sapiens (human) ]

Gene ID: 93129, updated on 9-Aug-2021

Summary

Official Symbol
ORAI3provided by HGNC
Official Full Name
ORAI calcium release-activated calcium modulator 3provided by HGNC
Primary source
HGNC:HGNC:28185
See related
Ensembl:ENSG00000175938 MIM:610930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM142C
Expression
Ubiquitous expression in prostate (RPKM 8.2), testis (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

See ORAI3 in Genome Data Viewer
Location:
16p11.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30949068..30954938)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30960389..30966259)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cardiotrophin 2, pseudogene Neighboring gene FBXL19 antisense RNA 1 Neighboring gene F-box and leucine rich repeat protein 19 Neighboring gene SET domain containing 1A, histone lysine methyltransferase Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC13024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein orai-3
Names
transmembrane protein 142C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152288.3NP_689501.1  protein orai-3

    See identical proteins and their annotated locations for NP_689501.1

    Status: VALIDATED

    Source sequence(s)
    AC135048
    Consensus CDS
    CCDS10697.1
    UniProtKB/Swiss-Prot
    Q9BRQ5
    UniProtKB/TrEMBL
    A0A024QZA7
    Related
    ENSP00000322249.4, ENST00000318663.5
    Conserved Domains (1) summary
    pfam07856
    Location:48276
    Orai-1; Mediator of CRAC channel activity

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    30949068..30954938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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