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KCNG4 potassium voltage-gated channel modifier subfamily G member 4 [ Homo sapiens (human) ]

Gene ID: 93107, updated on 1-Aug-2020

Summary

Official Symbol
KCNG4provided by HGNC
Official Full Name
potassium voltage-gated channel modifier subfamily G member 4provided by HGNC
Primary source
HGNC:HGNC:19697
See related
Ensembl:ENSG00000168418 MIM:607603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KV6.3; KV6.4
Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KCNG4 in Genome Data Viewer
Location:
16q24.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (84221135..84239750, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (84254741..84273356, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3417 Neighboring gene splicing factor proline/glutamine-rich Neighboring gene adenosine deaminase domain containing 2 Neighboring gene RNA, 5S ribosomal pseudogene 433 Neighboring gene WAP four-disulfide core domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4558, MGC129609

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily G member 4
Names
potassium channel, voltage gated modifier subfamily G, member 4
potassium voltage-gated channel, subfamily G, member 4
voltage-gated potassium channel Kv6.3
voltage-gated potassium channel subunit Kv6.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172347.2NP_758857.1  potassium voltage-gated channel subfamily G member 4

    See identical proteins and their annotated locations for NP_758857.1

    Status: REVIEWED

    Source sequence(s)
    AC009123, BC008969, BC109203, BQ185567
    Consensus CDS
    CCDS10945.1
    UniProtKB/Swiss-Prot
    Q8TDN1
    UniProtKB/TrEMBL
    Q32MC1, Q547S7
    Related
    ENSP00000312129.4, ENST00000308251.5
    Conserved Domains (4) summary
    smart00225
    Location:61161
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:262465
    Ion_trans; Ion transport protein
    pfam02214
    Location:61160
    BTB_2; BTB/POZ domain
    pfam07885
    Location:377459
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    84221135..84239750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133490.2: Suppressed sequence

    Description
    NM_133490.2: This RefSeq was permanently suppressed because its source, BC008969.1, is from a cancerous cell line.
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