Format

Send to:

Choose Destination

DMKN dermokine [ Homo sapiens (human) ]

Gene ID: 93099, updated on 13-Mar-2020

Summary

Official Symbol
DMKNprovided by HGNC
Official Full Name
dermokineprovided by HGNC
Primary source
HGNC:HGNC:25063
See related
Ensembl:ENSG00000161249 MIM:617211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ729; ZD52F10
Summary
This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in skin (RPKM 387.3) and esophagus (RPKM 47.0) See more
Orthologs

Genomic context

See DMKN in Genome Data Viewer
Location:
19q13.12
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35497220..35513678, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35988119..36004560, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene free fatty acid receptor 2 Neighboring gene keratinocyte differentiation associated protein Neighboring gene suprabasin Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene TMEM147 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ79374

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cornified envelope assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dermokine
Names
epidermis-specific secreted protein SK30/SK89

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035516.4NP_001030593.2  dermokine isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (1, also referred to as isoform alpha) has a distinct N-terminus and is shorter than isoform 2.
    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS42549.1
    Related
    ENSP00000386225.2, ENST00000408915.6
  2. NM_001126056.3NP_001119528.3  dermokine isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and contains three additional alternate in-frame exons in the coding region, compared to variant 2. This results in a shorter protein (isoform 3, also referred to as isoform beta-2), compared to isoform 2.
    Source sequence(s)
    AC138125, AD001502
    Consensus CDS
    CCDS46054.2
    Related
    ENSP00000391036.1, ENST00000419602.5
  3. NM_001126057.3NP_001119529.2  dermokine isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (5, also referred to as isoform gamma 2) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AC138125, AY358412, AY789697
    Consensus CDS
    CCDS46053.1
    UniProtKB/Swiss-Prot
    Q6E0U4
    Related
    ENSP00000388404.2, ENST00000424570.6
  4. NM_001126058.3NP_001119530.2  dermokine isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (4, also referred to as isoform gamma 1) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AC138125, AY358412, AY789696
    Consensus CDS
    CCDS46052.1
    UniProtKB/Swiss-Prot
    Q6E0U4
    Related
    ENSP00000414743.1, ENST00000418261.5
  5. NM_001126059.4NP_001119531.2  dermokine isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (6, also referred to as isoform delta) has a distinct N-terminus and is shorter than isoform 2.
    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS46051.1
    Related
    ENSP00000392222.2, ENST00000414866.6
  6. NM_001190347.2NP_001177276.2  dermokine isoform 8 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon and contains two additional alternate in-frame exons in the coding region, compared to variant 2. This results in a shorter protein (isoform 8, also referred to as isoform beta-1), compared to isoform 2.
    Source sequence(s)
    AC138125, AD001502
    Consensus CDS
    CCDS54250.1
    Related
    ENSP00000405503.1, ENST00000429837.5
  7. NM_001190348.2NP_001177277.1  dermokine isoform 9 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple difference compared to variant 2. This variant encodes isoform 9, which is shorter than isoform 2.
    Source sequence(s)
    AC138125, AY358412, AY789697, EF158326
    Consensus CDS
    CCDS54252.1
    UniProtKB/Swiss-Prot
    Q6E0U4
    UniProtKB/TrEMBL
    A3EZ84
    Related
    ENSP00000394908.2, ENST00000447113.6
  8. NM_001190349.2NP_001177278.1  dermokine isoform 10 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple difference compared to variant 2. This variant encodes isoform 10 (also referred to as isoform gamma 1), which is shorter than isoform 2.
    Source sequence(s)
    AC138125, AY358412, AY789697
    Consensus CDS
    CCDS54251.1
    UniProtKB/Swiss-Prot
    Q6E0U4
    Related
    ENSP00000409513.2, ENST00000451297.6
  9. NM_001308380.2NP_001295309.2  dermokine isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and has multiple coding region differences, one of which results in use of an alternate start codon and novel 5' coding region compared to variant 2. It encodes isoform 11, which is shorter than and has a distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS77279.1
    Related
    ENSP00000384509.2, ENST00000402589.6
  10. NM_001308383.2NP_001295312.2  dermokine isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and has multiple coding region differences, one of which results in use of an alternate start codon and novel 5' coding region compared to variant 2. It encodes isoform 12, which is shorter than and has a distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS77278.1
    Related
    ENSP00000412075.1, ENST00000436012.5
  11. NM_001352328.2NP_001339257.2  dermokine isoform 13

    Status: REVIEWED

    Source sequence(s)
    AD001502
  12. NM_001352329.2NP_001339258.2  dermokine isoform 14

    Status: REVIEWED

    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS86745.1
    Related
    ENSP00000473341.2, ENST00000472252.6
  13. NM_001352330.2NP_001339259.2  dermokine isoform 14

    Status: REVIEWED

    Source sequence(s)
    AD001502
    Consensus CDS
    CCDS86745.1
  14. NM_001352331.2NP_001339260.1  dermokine isoform 15

    Status: REVIEWED

    Source sequence(s)
    CD174636, CD388805, EF158325
    Consensus CDS
    CCDS86747.1
    Related
    ENSP00000376042.2, ENST00000392206.6
  15. NM_001352332.2NP_001339261.1  dermokine isoform 16

    Status: REVIEWED

    Source sequence(s)
    CD388805
    Consensus CDS
    CCDS86746.1
    Related
    ENSP00000473191.1, ENST00000488892.5
  16. NM_033317.5NP_201574.4  dermokine isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2, also referred to as isoform beta).
    Source sequence(s)
    AC138125, AD001502
    Consensus CDS
    CCDS12463.1
    Related
    ENSP00000342012.3, ENST00000339686.8

RNA

  1. NR_033746.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs at its 5' end compared to variant 2. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF compared to variant 2; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AD001502
    Related
    ENST00000462721.5
  2. NR_147958.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    CD173452, EF158325
    Related
    ENST00000480507.1
  3. NR_147959.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AD001502
    Related
    ENST00000488542.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35497220..35513678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527507.2XP_011525809.1  dermokine isoform X12

  2. XM_011527499.2XP_011525801.1  dermokine isoform X4

  3. XM_011527509.2XP_011525811.1  dermokine isoform X14

  4. XM_024451775.1XP_024307543.1  dermokine isoform X14

  5. XM_011527508.2XP_011525810.1  dermokine isoform X13

  6. XM_011527505.2XP_011525807.1  dermokine isoform X10

  7. XM_011527506.2XP_011525808.1  dermokine isoform X11

  8. XM_011527502.2XP_011525804.1  dermokine isoform X7

  9. XM_011527503.2XP_011525805.1  dermokine isoform X8

  10. XM_011527496.2XP_011525798.1  dermokine isoform X2

  11. XM_011527504.2XP_011525806.1  dermokine isoform X9

  12. XM_011527500.2XP_011525802.1  dermokine isoform X5

  13. XM_011527501.2XP_011525803.1  dermokine isoform X6

  14. XM_011527497.2XP_011525799.1  dermokine isoform X3

    See identical proteins and their annotated locations for XP_011525799.1

  15. XM_011527498.2XP_011525800.1  dermokine isoform X3

    See identical proteins and their annotated locations for XP_011525800.1

  16. XM_011527494.2XP_011525796.1  dermokine isoform X1

    See identical proteins and their annotated locations for XP_011525796.1

  17. XM_011527495.2XP_011525797.1  dermokine isoform X1

    See identical proteins and their annotated locations for XP_011525797.1

  18. XM_006723503.3XP_006723566.1  dermokine isoform X20

    See identical proteins and their annotated locations for XP_006723566.1

  19. XM_011527513.1XP_011525815.1  dermokine isoform X18

  20. XM_006723484.1XP_006723547.1  dermokine isoform X16

  21. XM_017027475.1XP_016882964.1  dermokine isoform X17

    Related
    ENSP00000388378.1, ENST00000434389.5
  22. XM_024451776.1XP_024307544.1  dermokine isoform X19

    Related
    ENSP00000471112.1, ENST00000467637.5
  23. XM_006723477.1XP_006723540.1  dermokine isoform X15

    UniProtKB/TrEMBL
    C9IYI1
    Related
    ENSP00000406864.1, ENST00000443640.5
  24. XM_024451779.1XP_024307547.1  dermokine isoform X24

    Related
    ENSP00000474419.1, ENST00000492341.6
  25. XM_024451778.1XP_024307546.1  dermokine isoform X24

  26. XM_024451777.1XP_024307545.1  dermokine isoform X23

  27. XM_006723494.2XP_006723557.1  dermokine isoform X22

    UniProtKB/Swiss-Prot
    Q6E0U4
  28. XM_006723493.2XP_006723556.1  dermokine isoform X21

    UniProtKB/Swiss-Prot
    Q6E0U4
  29. XM_006723489.1XP_006723552.1  dermokine isoform X20

    See identical proteins and their annotated locations for XP_006723552.1

RNA

  1. XR_935874.2 RNA Sequence

  2. XR_935873.2 RNA Sequence

  3. XR_935872.2 RNA Sequence

  4. XR_935871.2 RNA Sequence

  5. XR_002958384.1 RNA Sequence

  6. XR_002958383.1 RNA Sequence

Support Center