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COQ10A coenzyme Q10A [ Homo sapiens (human) ]

Gene ID: 93058, updated on 24-Nov-2020

Summary

Official Symbol
COQ10Aprovided by HGNC
Official Full Name
coenzyme Q10Aprovided by HGNC
Primary source
HGNC:HGNC:26515
See related
Ensembl:ENSG00000135469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in heart (RPKM 31.5), adrenal (RPKM 13.0) and 20 other tissues See more
Orthologs

Genomic context

See COQ10A in Genome Data Viewer
Location:
12q13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56266942..56270966)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56660642..56664750)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene nucleic acid binding protein 2 Neighboring gene solute carrier family 39 member 5 Neighboring gene ankyrin repeat domain 52 Neighboring gene citrate synthase Neighboring gene uncharacterized LOC112268098 Neighboring gene canopy FGF signaling regulator 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquinone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular respiration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
coenzyme Q-binding protein COQ10 homolog A, mitochondrial
Names
coenzyme Q10 homolog A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099337.2NP_001092807.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001092807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, which produces a unique 5' UTR and causes translation initiation at a unique start codon, compared to variant 1. The encoded protein (isoform b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BC026922
    Consensus CDS
    CCDS44921.1
    UniProtKB/Swiss-Prot
    Q96MF6
    Related
    ENSP00000407843.2, ENST00000433805.6
    Conserved Domains (1) summary
    cd07813
    Location:55193
    COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins
  2. NM_144576.4NP_653177.3  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_653177.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC073923, DB271789
    Consensus CDS
    CCDS41796.1
    UniProtKB/Swiss-Prot
    Q96MF6
    Related
    ENSP00000312587.5, ENST00000308197.9
    Conserved Domains (1) summary
    cd07813
    Location:87225
    COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56266942..56270966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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