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MARCHF9 membrane associated ring-CH-type finger 9 [ Homo sapiens (human) ]

Gene ID: 92979, updated on 14-Oct-2019

Summary

Official Symbol
MARCHF9provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 9provided by HGNC
Primary source
HGNC:HGNC:25139
See related
Ensembl:ENSG00000139266 MIM:613336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARCH9; RNF179; MARCH-IX
Summary
MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010]
Expression
Ubiquitous expression in kidney (RPKM 5.4), spleen (RPKM 4.4) and 25 other tissues See more
Orthologs

Genomic context

See MARCHF9 in Genome Data Viewer
Location:
12q14.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (57755103..57760411)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (58148881..58154193)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene AGAP2 antisense RNA 1 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Neighboring gene tetraspanin 31 Neighboring gene microRNA 6759 Neighboring gene cyclin dependent kinase 4 Neighboring gene cytochrome P450 family 27 subfamily B member 1 Neighboring gene methyltransferase like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transferase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCH9
Names
RING finger protein 179
RING-type E3 ubiquitin transferase MARCH9
membrane associated ring finger 9
membrane-associated RING finger protein 9
membrane-associated RING-CH protein IX
membrane-associated ring finger (C3HC4) 9
NP_612405.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138396.6NP_612405.2  E3 ubiquitin-protein ligase MARCH9 precursor

    See identical proteins and their annotated locations for NP_612405.2

    Status: VALIDATED

    Source sequence(s)
    AC025165, AK093897, BC050397
    Consensus CDS
    CCDS31847.1
    UniProtKB/Swiss-Prot
    Q86YJ5
    UniProtKB/TrEMBL
    Q8N9T1
    Related
    ENSP00000266643.5, ENST00000266643.6
    Conserved Domains (1) summary
    smart00744
    Location:109155
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    57755103..57760411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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