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PEX11G peroxisomal biogenesis factor 11 gamma [ Homo sapiens (human) ]

Gene ID: 92960, updated on 22-Sep-2022

Summary

Official Symbol
PEX11Gprovided by HGNC
Official Full Name
peroxisomal biogenesis factor 11 gammaprovided by HGNC
Primary source
HGNC:HGNC:20208
See related
Ensembl:ENSG00000104883 MIM:607583; AllianceGenome:HGNC:20208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEX11gamma
Summary
The protein encoded by this gene is a member of the PEX11 family. This family is reported to regulate the number and size of peroxisomes in evolutionarily distant organisms. The protein encoded by this gene may induce clustering of peroxisomes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Broad expression in testis (RPKM 3.6), kidney (RPKM 2.2) and 23 other tissues See more
Orthologs
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Genomic context

See PEX11G in Genome Data Viewer
Location:
19p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7476875..7494977, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7477542..7490067, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7541761..7554286, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene insulin receptor Neighboring gene uncharacterized LOC124904626 Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene uncharacterized LOC107985284 Neighboring gene Sharpr-MPRA regulatory region 11228 Neighboring gene uncharacterized LOC105372261 Neighboring gene testis expressed 45 Neighboring gene zinc finger protein 358

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4281

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peroxisome fission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of peroxisome size IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal membrane protein 11C
Names
PEX11-gamma
Peroxisomal membrane protein 11G
Pex11pgamma
peroxin Pex11p gamma
peroxin-11C
peroxisomal biogenesis factor 11C
peroxisomal biogenesis factor 11G
protein PEX11 homolog gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270539.2NP_001257468.1  peroxisomal membrane protein 11C isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC008780, BI833221, HY002496
    UniProtKB/Swiss-Prot
    Q96HA9
    Related
    ENSP00000472956.1, ENST00000593547.1
    Conserved Domains (1) summary
    pfam05648
    Location:4160
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  2. NM_001300881.2NP_001287810.1  peroxisomal membrane protein 11C isoform 3

    See identical proteins and their annotated locations for NP_001287810.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL833945, BC008780
    Consensus CDS
    CCDS77227.1
    UniProtKB/Swiss-Prot
    Q96HA9
    Conserved Domains (1) summary
    pfam05648
    Location:1159
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  3. NM_080662.4NP_542393.1  peroxisomal membrane protein 11C isoform 1

    See identical proteins and their annotated locations for NP_542393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC008780, HY002496
    Consensus CDS
    CCDS12178.1
    UniProtKB/Swiss-Prot
    Q8NDM0, Q96HA9
    Related
    ENSP00000221480.1, ENST00000221480.6
    Conserved Domains (1) summary
    pfam05648
    Location:4229
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    7476875..7494977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528428.1XP_011526730.1  peroxisomal membrane protein 11C isoform X4

    See identical proteins and their annotated locations for XP_011526730.1

    UniProtKB/Swiss-Prot
    Q96HA9
    Related
    ENSP00000472216.1, ENST00000593942.5
    Conserved Domains (1) summary
    pfam05648
    Location:1159
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  2. XM_011528429.3XP_011526731.1  peroxisomal membrane protein 11C isoform X4

    See identical proteins and their annotated locations for XP_011526731.1

    UniProtKB/Swiss-Prot
    Q96HA9
    Conserved Domains (1) summary
    pfam05648
    Location:1159
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  3. XM_011528431.3XP_011526733.1  peroxisomal membrane protein 11C isoform X4

    See identical proteins and their annotated locations for XP_011526733.1

    UniProtKB/Swiss-Prot
    Q96HA9
    Conserved Domains (1) summary
    pfam05648
    Location:1159
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  4. XM_011528432.2XP_011526734.1  peroxisomal membrane protein 11C isoform X5

    Conserved Domains (1) summary
    pfam05648
    Location:4146
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  5. XM_005272506.3XP_005272563.1  peroxisomal membrane protein 11C isoform X2

    Conserved Domains (1) summary
    pfam05648
    Location:4208
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  6. XM_011528427.3XP_011526729.1  peroxisomal membrane protein 11C isoform X3

    Conserved Domains (1) summary
    pfam05648
    Location:4143
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  7. XM_011528426.3XP_011526728.1  peroxisomal membrane protein 11C isoform X1

    Conserved Domains (1) summary
    pfam05648
    Location:4143
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    7477542..7490067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)