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ATP6V1F ATPase H+ transporting V1 subunit F [ Homo sapiens (human) ]

Gene ID: 9296, updated on 22-May-2022

Summary

Official Symbol
ATP6V1Fprovided by HGNC
Official Full Name
ATPase H+ transporting V1 subunit Fprovided by HGNC
Primary source
HGNC:HGNC:16832
See related
Ensembl:ENSG00000128524 MIM:607160; AllianceGenome:HGNC:16832
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VATF; Vma7; ATP6S14
Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 97.5), brain (RPKM 77.0) and 25 other tissues See more
Orthologs
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Genomic context

See ATP6V1F in Genome Data Viewer
Location:
7q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (128862856..128865847)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (130175783..130178774)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128502910..128505901)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 136 Neighboring gene filamin C Neighboring gene FLNC antisense RNA 1 Neighboring gene ATP6V1F neighbor Neighboring gene Sharpr-MPRA regulatory region 1680 Neighboring gene kielin cysteine rich BMP regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117321, MGC126037, MGC126038

Gene Ontology Provided by GOA

General protein information

Preferred Names
V-type proton ATPase subunit F
Names
ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
ATPase, vacuolar, 14 kD
H(+)-transporting two-sector ATPase, 14kD subunit
V-ATPase 14 kDa subunit
V-ATPase F subunit
V-ATPase subunit F
adenosinetriphosphatase 14k chain
vacuolar ATP synthase subunit F
vacuolar proton pump F subunit
vacuolar proton pump subunit F
NP_001185838.1
NP_004222.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198909.2NP_001185838.1  V-type proton ATPase subunit F isoform 2

    See identical proteins and their annotated locations for NP_001185838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate, in-frame, exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is longer when it is compared to isoform 1.
    Source sequence(s)
    BC107854, BU683155, BU956696
    Consensus CDS
    CCDS56511.1
    UniProtKB/Swiss-Prot
    Q16864
    Related
    ENSP00000417378.1, ENST00000492758.1
    Conserved Domains (1) summary
    TIGR01101
    Location:1143
    V_ATP_synt_F; vacuolar ATP synthase F subunit
  2. NM_004231.4NP_004222.2  V-type proton ATPase subunit F isoform 1

    See identical proteins and their annotated locations for NP_004222.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript.
    Source sequence(s)
    BC107854, BU683155
    Consensus CDS
    CCDS5807.1
    UniProtKB/Swiss-Prot
    Q16864
    UniProtKB/TrEMBL
    A4D1K0
    Related
    ENSP00000249289.4, ENST00000249289.5
    Conserved Domains (1) summary
    TIGR01101
    Location:1115
    V_ATP_synt_F; vacuolar ATP synthase F subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    128862856..128865847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    130175783..130178774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)