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S1PR2 sphingosine-1-phosphate receptor 2 [ Homo sapiens (human) ]

Gene ID: 9294, updated on 11-Sep-2019

Summary

Official Symbol
S1PR2provided by HGNC
Official Full Name
sphingosine-1-phosphate receptor 2provided by HGNC
Primary source
HGNC:HGNC:3169
See related
Ensembl:ENSG00000267534 MIM:605111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG5; H218; LPB2; S1P2; AGR16; EDG-5; DFNB68; Gpcr13
Summary
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
Expression
Broad expression in placenta (RPKM 10.4), lymph node (RPKM 5.1) and 22 other tissues See more
Orthologs

Genomic context

See S1PR2 in Genome Data Viewer
Location:
19p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10221433..10231331, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10332109..10341948, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 1 Neighboring gene origin of replication in DNMT1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 pseudogene Neighboring gene microRNA 4322 Neighboring gene uncharacterized LOC105372272 Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene intercellular adhesion molecule 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DNMT1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipid binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sphingosine-1-phosphate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sphingosine 1-phosphate receptor 2
Names
CTD-2369P2.2
S1P receptor 2
S1P receptor EDG5
S1P receptor Edg-5
deafness, autosomal recessive 68
endothelial differentiation G-protein coupled receptor 5
endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
sphingosine 1-phosphate receptor Edg-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046802.1 RefSeqGene

    Range
    5477..15375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004230.4NP_004221.3  sphingosine 1-phosphate receptor 2

    See identical proteins and their annotated locations for NP_004221.3

    Status: REVIEWED

    Source sequence(s)
    AC011511, BC069598, BF513287, BG055846
    Consensus CDS
    CCDS12229.1
    UniProtKB/Swiss-Prot
    O95136
    UniProtKB/TrEMBL
    A0A024R7B2
    Related
    ENSP00000496438.1, ENST00000646641.1
    Conserved Domains (1) summary
    cd15347
    Location:34299
    7tmA_S1PR2_Edg5; sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10221433..10231331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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