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S1PR2 sphingosine-1-phosphate receptor 2 [ Homo sapiens (human) ]

Gene ID: 9294, updated on 17-Jun-2024

Summary

Official Symbol
S1PR2provided by HGNC
Official Full Name
sphingosine-1-phosphate receptor 2provided by HGNC
Primary source
HGNC:HGNC:3169
See related
Ensembl:ENSG00000267534 MIM:605111; AllianceGenome:HGNC:3169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG5; H218; LPB2; S1P2; AGR16; EDG-5; DFNB68; Gpcr13
Summary
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
Expression
Broad expression in placenta (RPKM 10.4), lymph node (RPKM 5.1) and 22 other tissues See more
Orthologs
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Genomic context

See S1PR2 in Genome Data Viewer
Location:
19p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10221433..10231331, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10347578..10357458, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10332109..10342007, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:10246117-10247316 Neighboring gene DNA methyltransferase 1 Neighboring gene origin of replication in DNMT1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10294611-10295111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13940 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10310838-10311338 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10330242-10330742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10330743-10331243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10340651-10341365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13947 Neighboring gene Sharpr-MPRA regulatory region 3154 Neighboring gene microRNA 4322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10060 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:10362245-10362818 and GRCh37_chr19:10362819-10363392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13951 Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene Sharpr-MPRA regulatory region 14536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13953 Neighboring gene lncRNA inflammatory and mucous response associated, antisense to ICAM1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13954 Neighboring gene intercellular adhesion molecule 1 Neighboring gene ICAM4 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DNMT1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sphingosine-1-phosphate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sphingosine-1-phosphate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sphingosine-1-phosphate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sphingosine 1-phosphate receptor 2
Names
CTD-2369P2.2
S1P receptor 2
S1P receptor EDG5
S1P receptor Edg-5
deafness, autosomal recessive 68
endothelial differentiation G-protein coupled receptor 5
endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
sphingosine 1-phosphate receptor Edg-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046802.1 RefSeqGene

    Range
    5477..15375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1356

mRNA and Protein(s)

  1. NM_004230.4NP_004221.3  sphingosine 1-phosphate receptor 2

    See identical proteins and their annotated locations for NP_004221.3

    Status: REVIEWED

    Source sequence(s)
    AC011511, BC069598, BF513287, BG055846
    Consensus CDS
    CCDS12229.1
    UniProtKB/Swiss-Prot
    O95136, Q86UN8
    Related
    ENSP00000496438.1, ENST00000646641.1
    Conserved Domains (1) summary
    cd15347
    Location:34299
    7tmA_S1PR2_Edg5; sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10221433..10231331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10347578..10357458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)