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UBE2Q2 ubiquitin conjugating enzyme E2 Q2 [ Homo sapiens (human) ]

Gene ID: 92912, updated on 23-Nov-2021

Summary

Official Symbol
UBE2Q2provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Q2provided by HGNC
Primary source
HGNC:HGNC:19248
See related
Ensembl:ENSG00000140367 MIM:612501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 12.2), prostate (RPKM 10.7) and 25 other tissues See more
Orthologs
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Genomic context

See UBE2Q2 in Genome Data Viewer
Location:
15q24.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (75843343..75901078)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (76135788..76193419)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene dynamin 1 pseudogene 49 Neighboring gene Sharpr-MPRA regulatory region 8353 Neighboring gene RNA, 7SL, cytoplasmic 510, pseudogene Neighboring gene F-box protein 22 Neighboring gene neuregulin 4 Neighboring gene transmembrane protein 266 Neighboring gene uncharacterized LOC101929439

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
GeneReviews: Not available
New loci associated with kidney function and chronic kidney disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762C143

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 Q2
Names
E2 ubiquitin-conjugating enzyme Q2
ubiquitin carrier protein Q2
ubiquitin conjugating enzyme E2Q family member 2
ubiquitin-protein ligase Q2
NP_001138807.1
NP_001271311.1
NP_775740.1
XP_005254844.1
XP_005254845.1
XP_006720833.1
XP_011520530.1
XP_016878215.1
XP_016878216.1
XP_016878217.1
XP_024305875.1
XP_024305876.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145335.1NP_001138807.1  ubiquitin-conjugating enzyme E2 Q2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA476260, AC027104, AK296234, BC017708
    Consensus CDS
    CCDS45309.1
    UniProtKB/Swiss-Prot
    Q8WVN8
    Related
    ENSP00000456229.1, ENST00000561851.5
    Conserved Domains (1) summary
    cd00195
    Location:190346
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_001284382.2NP_001271311.1  ubiquitin-conjugating enzyme E2 Q2 isoform 3

    See identical proteins and their annotated locations for NP_001271311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC019294, AC027104
    Consensus CDS
    CCDS66839.1
    UniProtKB/Swiss-Prot
    Q8WVN8
    Related
    ENSP00000456324.1, ENST00000569423.5
    Conserved Domains (2) summary
    cd00195
    Location:171327
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cl02687
    Location:994
    RWD; RWD domain
  3. NM_173469.4NP_775740.1  ubiquitin-conjugating enzyme E2 Q2 isoform 1

    See identical proteins and their annotated locations for NP_775740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC019294, AC027104
    Consensus CDS
    CCDS10286.1
    UniProtKB/Swiss-Prot
    Q8WVN8
    Related
    ENSP00000267938.4, ENST00000267938.9
    Conserved Domains (2) summary
    cd00195
    Location:206362
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cl02687
    Location:994
    RWD; RWD domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    75843343..75901078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254787.2XP_005254844.1  ubiquitin-conjugating enzyme E2 Q2 isoform X1

    Conserved Domains (2) summary
    cl00154
    Location:206314
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cl02687
    Location:994
    RWD; RWD domain
  2. XM_005254788.2XP_005254845.1  ubiquitin-conjugating enzyme E2 Q2 isoform X3

    Conserved Domains (2) summary
    cl00154
    Location:194283
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cl02687
    Location:994
    RWD; RWD domain
  3. XM_006720770.2XP_006720833.1  ubiquitin-conjugating enzyme E2 Q2 isoform X7

    Conserved Domains (1) summary
    cl02687
    Location:994
    RWD; RWD domain
  4. XM_017022727.2XP_016878216.1  ubiquitin-conjugating enzyme E2 Q2 isoform X5

  5. XM_017022728.2XP_016878217.1  ubiquitin-conjugating enzyme E2 Q2 isoform X6

  6. XM_024450107.1XP_024305875.1  ubiquitin-conjugating enzyme E2 Q2 isoform X2

    Conserved Domains (2) summary
    cl00154
    Location:206288
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cl02687
    Location:994
    RWD; RWD domain
  7. XM_024450108.1XP_024305876.1  ubiquitin-conjugating enzyme E2 Q2 isoform X8

    Conserved Domains (1) summary
    cl02687
    Location:994
    RWD; RWD domain
  8. XM_011522228.2XP_011520530.1  ubiquitin-conjugating enzyme E2 Q2 isoform X9

    Conserved Domains (1) summary
    cl02687
    Location:994
    RWD; RWD domain
  9. XM_017022726.1XP_016878215.1  ubiquitin-conjugating enzyme E2 Q2 isoform X4

RNA

  1. XR_002957691.1 RNA Sequence

  2. XR_001751420.2 RNA Sequence

  3. XR_002957692.1 RNA Sequence

  4. XR_001751421.2 RNA Sequence

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