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HNRNPLL heterogeneous nuclear ribonucleoprotein L like [ Homo sapiens (human) ]

Gene ID: 92906, updated on 19-Dec-2019

Summary

Official Symbol
HNRNPLLprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein L likeprovided by HGNC
Primary source
HGNC:HGNC:25127
See related
Ensembl:ENSG00000143889 MIM:611208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRRF; HNRPLL
Summary
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
Expression
Ubiquitous expression in testis (RPKM 17.8), thyroid (RPKM 11.5) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPLL in Genome Data Viewer
Location:
2p22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (38561969..38603036, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38789120..38830178, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2666 Neighboring gene long intergenic non-protein coding RNA 2613 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 6 Neighboring gene CRISPRi-validated cis-regulatory element chr2.1526 Neighboring gene CRISPRi-validated cis-regulatory element chr2.1528

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
positive regulation of RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
membrane HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein L-like
Names
stromal RNA regulating factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142650.1NP_001136122.1  heterogeneous nuclear ribonucleoprotein L-like isoform 2

    See identical proteins and their annotated locations for NP_001136122.1

    Status: VALIDATED

    Description
    Transcript Variant: Compared to variant 1, this variant (2) lacks a segment of the 5' UTR which results in the use of an alternative translation initiation site. These differences result in a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK000155, AK292259, BM972334, DA760455
    Consensus CDS
    CCDS46261.1
    UniProtKB/Swiss-Prot
    Q8WVV9
    UniProtKB/TrEMBL
    A8K894
    Related
    ENSP00000387088.1, ENST00000409636.5
    Conserved Domains (1) summary
    TIGR01649
    Location:69536
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  2. NM_138394.4NP_612403.2  heterogeneous nuclear ribonucleoprotein L-like isoform 1

    See identical proteins and their annotated locations for NP_612403.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011247, AK000155, BC017480, BM972334, DA760455
    Consensus CDS
    CCDS1796.2
    UniProtKB/Swiss-Prot
    Q8WVV9
    UniProtKB/TrEMBL
    A0A0S2Z6K1
    Related
    ENSP00000390625.3, ENST00000449105.8
    Conserved Domains (1) summary
    TIGR01649
    Location:74541
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    38561969..38603036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264639.4XP_005264696.2  heterogeneous nuclear ribonucleoprotein L-like isoform X1

    Conserved Domains (6) summary
    COG0724
    Location:15128
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12700
    Location:336406
    RRM3_hnRPLL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12781
    Location:73156
    RRM1_hnRPLL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12786
    Location:165260
    RRM2_hnRPLL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    TIGR01649
    Location:74524
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cl17169
    Location:452524
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_005264640.3XP_005264697.2  heterogeneous nuclear ribonucleoprotein L-like isoform X2

    Conserved Domains (6) summary
    COG0724
    Location:10123
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12700
    Location:331401
    RRM3_hnRPLL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12781
    Location:68151
    RRM1_hnRPLL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12786
    Location:160255
    RRM2_hnRPLL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    TIGR01649
    Location:69519
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cl17169
    Location:447519
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_011533165.3XP_011531467.1  heterogeneous nuclear ribonucleoprotein L-like isoform X3

    Conserved Domains (6) summary
    COG0724
    Location:15128
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12700
    Location:312382
    RRM3_hnRPLL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12781
    Location:73156
    RRM1_hnRPLL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12786
    Location:165260
    RRM2_hnRPLL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    TIGR01649
    Location:74500
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cl17169
    Location:428500
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_011533166.3XP_011531468.1  heterogeneous nuclear ribonucleoprotein L-like isoform X4

    Conserved Domains (6) summary
    COG0724
    Location:15128
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12700
    Location:336406
    RRM3_hnRPLL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12781
    Location:73156
    RRM1_hnRPLL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12786
    Location:165260
    RRM2_hnRPLL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    TIGR01649
    Location:74524
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cl17169
    Location:452524
    RRM_SF; RNA recognition motif (RRM) superfamily
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